TPH1
Summary: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tryptophan hydroxylase 1 | MIM:191060 | Ensembl:ENSG00000129167 | HGNC:HGNC:12008 | PA355 | 11p15.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TPH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004510 | tryptophan 5-monooxygenase activity |
| MF | IEA | GO:0005506 | iron ion binding |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0043005 | neuron projection |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0009072 | aromatic amino acid family metabolic process |
| BP | IEA | GO:0030279 | negative regulation of ossification |
| BP | IEA | GO:0035902 | response to immobilization stress |
| BP | IEA | GO:0042427 | serotonin biosynthetic process |
| BP | IEA | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IEA | GO:0046849 | bone remodeling |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
Gene expression in normal tissue: TPH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPH1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-209776 | Amine-derived hormones |
| reactome | R-HSA-209931 | Serotonin and melatonin biosynthesis |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| humancyc | PWY-6030 | serotonin and melatonin biosynthesis |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| pharmgkb | PA161749006 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| kegg | hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| smpdb | SMP00063 | Tryptophan Metabolism |
| wikipathways | WP3925 | Amino Acid metabolism |
| wikipathways | WP465 | Tryptophan metabolism |
| wikipathways | WP550 | Biogenic Amine Synthesis |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 6 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD511 | CHEMBL399379 | 4 |
| iGMDRD123 | Isoevodiamine | 8 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD103 | SN-38 | 8 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TPH1
CLASSFICATION
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