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TPH1

Summary: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametryptophan hydroxylase 1 OMIM IDMIM:191060 Ensembl IDEnsembl:ENSG00000129167 HGNC IDHGNC:HGNC:12008 PHARMGKB IDPA355 Map Location11p15.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TPH1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004510	tryptophan 5-monooxygenase activity
MF	IEA	GO:0005506	iron ion binding
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0043005	neuron projection
BP	IEA	GO:0007623	circadian rhythm
BP	IEA	GO:0009072	aromatic amino acid family metabolic process

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Gene expression in normal tissue: TPH1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TPH1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-209776	Amine-derived hormones
reactome	R-HSA-209931	Serotonin and melatonin biosynthesis
reactome	R-HSA-71291	Metabolism of amino acids and derivatives
humancyc	PWY-6030	serotonin and melatonin biosynthesis
humancyc	PWY66-401	superpathway of tryptophan utilization

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD351	GW843682X	6
iGMDRD888	Compound 44	1
iGMDRD237	ABT-751	2
iGMDRD511	CHEMBL399379	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TPH1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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