PGAP3
Summary: This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| post-GPI attachment to proteins 3 | MIM:611801 | Ensembl:ENSG00000161395 | HGNC:HGNC:23719 | PA165432310 | 17q12 |
GO terms in PGAP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031227 | intrinsic component of endoplasmic reticulum membrane |
| CC | IDA | GO:0031227 | intrinsic component of endoplasmic reticulum membrane |
| BP | IMP | GO:0006505 | GPI anchor metabolic process |
| BP | IBA | GO:0006506 | GPI anchor biosynthetic process |
| BP | IEA | GO:0006506 | GPI anchor biosynthetic process |
| MF | IBA | GO:0016788 | hydrolase activity, acting on ester bonds |
| MF | IMP | GO:0016788 | hydrolase activity, acting on ester bonds |
Gene expression in normal tissue: PGAP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PGAP3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD366 | PI-103 | 13 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD506 | Fedratinib | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PGAP3
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