PAX8


Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
paired box 8MIM:167415Ensembl:ENSG00000125618HGNC:HGNC:8622PA329622q14.1

GO terms in PAX8


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFTASGO:0004996thyroid-stimulating hormone receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0044212transcription regulatory region DNA binding
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCISSGO:0005654nucleoplasm
BPISSGO:0001655urogenital system development
BPIEPGO:0001658branching involved in ureteric bud morphogenesis
BPIEPGO:0001822kidney development
BPISSGO:0001823mesonephros development
BPIEAGO:0003281ventricular septum development
BPIEPGO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIDAGO:0006351transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006790sulfur compound metabolic process
BPIEPGO:0007417central nervous system development
BPTASGO:0009653anatomical structure morphogenesis
BPIEAGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIEPGO:0030878thyroid gland development
BPIMPGO:0030878thyroid gland development
BPIEAGO:0038194thyroid-stimulating hormone signaling pathway
BPISSGO:0039003pronephric field specification
BPISSGO:0042472inner ear morphogenesis
BPISSGO:0042981regulation of apoptotic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048793pronephros development
BPIDAGO:0071371cellular response to gonadotropin stimulus
BPIEPGO:0071599otic vesicle development
BPISSGO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIEPGO:0072207metanephric epithelium development
BPISSGO:0072221metanephric distal convoluted tubule development
BPIEPGO:0072278metanephric comma-shaped body morphogenesis
BPIEPGO:0072284metanephric S-shaped body morphogenesis
BPISSGO:0072289metanephric nephron tubule formation
BPISSGO:0072305negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
BPISSGO:0072307regulation of metanephric nephron tubule epithelial cell differentiation
BPISSGO:0090190positive regulation of branching involved in ureteric bud morphogenesis
BPISSGO:1900212negative regulation of mesenchymal cell apoptotic process involved in metanephros development
BPISSGO:1900215negative regulation of apoptotic process involved in metanephric collecting duct development
BPISSGO:1900218negative regulation of apoptotic process involved in metanephric nephron tubule development
BPISSGO:2000594positive regulation of metanephric DCT cell differentiation
BPIMPGO:2000611positive regulation of thyroid hormone generation
BPIMPGO:2000612regulation of thyroid-stimulating hormone secretion

Gene expression in normal tissue: PAX8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAX8


DatabasePathway IDPathway Des.
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP53ID signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD513BML-2593
iGMDRD23Gossypol3
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole3
iGMDRD640CAY106183
iGMDRD188Piperlongumine3
iGMDRD887Compound 23 citrate3
iGMDRD144NSC953973
iGMDRD546BMS-7548072
iGMDRD1008SR-II-138A3
iGMDRD151CHM-11
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A1
iGMDRD639YK 4-2793
iGMDRD193Fqi11
iGMDRD446LY 21832401
iGMDRD481Dactolisib3
iGMDRD267Oligomycin A4
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide5
iGMDRD6AM-5803
iGMDRD103SN-386
iGMDRD202Curcumin6
iGMDRD82Quiflapon1
iGMDRD505Pevonedistat4
iGMDRD366PI-1036
iGMDRD414MST-3123
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD405PIK-753
iGMDRD701NVP-AUY9223
iGMDRD486Tosedostat4
iGMDRD123Isoevodiamine1
iGMDRD351GW843682X6
iGMDRD698Neratinib4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAX8

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