LTBR

Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namelymphotoxin beta receptor
OMIM IDMIM:600979
Ensembl IDEnsembl:ENSG00000111321
HGNC IDHGNC:HGNC:6718
PHARMGKB IDPA30481
Map Location12p13.31

Gene Categories:

DRUGGABLE GENOME

GO terms in LTBR


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IPI GO:0031625 ubiquitin protein ligase binding
MF IPI GO:0042802 identical protein binding
BP IEA GO:0006915 apoptotic process
BP TAS GO:0007165 signal transduction
BP IEA GO:0016032 viral process
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Gene expression in normal tissue: LTBR

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4

Gene-drug pathway distribution

undefined10DNA replication2Longevity regulating pathway1PI3K/MTOR signaling1Chromatin histone acetylation1ERK MAPK signaling1

Pathways in LTBR


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Database
Pathway ID
Pathway Des.
pharmgkb PA165374494 Busulfan Pathway, Pharmacodynamics
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
kegg hsa05166 HTLV-I infection - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD286 Nsc 632839 6
iGMDRD329 Merck60 6
iGMDRD353 PD0325901 2
iGMDRD524 ISX-9 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LTBR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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