TNFRSF12A
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 12A | MIM:605914 | Ensembl:ENSG00000006327 | HGNC:HGNC:18152 | PA134976874 | 16p13.3 |
GO terms in TNFRSF12A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045765 | regulation of angiogenesis |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | IDA | GO:0061041 | regulation of wound healing |
| BP | IEA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| CC | IEA | GO:0001726 | ruffle |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: TNFRSF12A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF12A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| netpath | Pathway_TWEAK | TWEAK |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF12A
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.