FLT4

Summary: This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namefms related tyrosine kinase 4
OMIM IDMIM:136352
Ensembl IDEnsembl:ENSG00000037280
HGNC IDHGNC:HGNC:3767
PHARMGKB IDPA28183
Map Location5q35.3

GO terms in FLT4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IMP GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IBA GO:0004888 transmembrane signaling receptor activity
MF IBA GO:0005021 vascular endothelial growth factor-activated receptor activity
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Gene expression in normal tissue: FLT4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 48BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 21OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 2

Gene-drug pathway distribution

undefined18Purine metabolism1Longevity regulating pathway1Cell cycle1Metabolism1ERK MAPK signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Other, kinases1

Pathways in FLT4


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Database
Pathway ID
Pathway Des.
pid lymphangiogenesis_pathway VEGFR3 signaling in lymphatic endothelium
pid vegf_vegfr_pathway VEGF and VEGFR signaling network
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD121 GMX1778 3
iGMDRD202 Curcumin 6
iGMDRD103 SN-38 2
iGMDRD192 CIL56 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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