FLT4


Summary: This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fms related tyrosine kinase 4MIM:136352Ensembl:ENSG00000037280HGNC:HGNC:3767PA281835q35.3

GO terms in FLT4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIMPGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005021vascular endothelial growth factor-activated receptor activity
MFIDAGO:0005021vascular endothelial growth factor-activated receptor activity
MFIMPGO:0005021vascular endothelial growth factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019838growth factor binding
MFIPIGO:0019903protein phosphatase binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIDAGO:0036328VEGF-C-activated receptor activity
MFIDAGO:0042803protein homodimerization activity
CCIEAGO:0005576extracellular region
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
BPIBAGO:0001570vasculogenesis
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPISSGO:0001944vasculature development
BPISSGO:0001945lymph vessel development
BPIMPGO:0001946lymphangiogenesis
BPISSGO:0001946lymphangiogenesis
BPIBAGO:0002040sprouting angiogenesis
BPISSGO:0002040sprouting angiogenesis
BPIEAGO:0003016respiratory system process
BPTASGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007275multicellular organism development
BPIGIGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIMPGO:0010575positive regulation of vascular endothelial growth factor production
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIDAGO:0038084vascular endothelial growth factor signaling pathway
BPIBAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0043410positive regulation of MAPK cascade
BPIMPGO:0046330positive regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIGIGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0048286lung alveolus development
BPISSGO:0048514blood vessel morphogenesis
BPISSGO:0060312regulation of blood vessel remodeling
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0090037positive regulation of protein kinase C signaling

Gene expression in normal tissue: FLT4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLT4


DatabasePathway IDPathway Des.
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidvegf_vegfr_pathwayVEGF and VEGFR signaling network
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194313VEGF ligand-receptor interactions
reactomeR-HSA-195399VEGF binds to VEGFR leading to receptor dimerization
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription
biocartano1pathwayactions of nitric oxide in the heart
biocartavegfpathwayvegf hypoxia and angiogenesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD121GMX17783
iGMDRD202Curcumin6
iGMDRD103SN-382
iGMDRD192CIL561
iGMDRD705Nakiterpiosin3
iGMDRD329Merck605
iGMDRD506Fedratinib1
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine2
iGMDRD286Nsc 6328393
iGMDRD414MST-3124
iGMDRD322FK 8663
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD512nutlin 33
iGMDRD151CHM-13
iGMDRD486Tosedostat2
iGMDRD79Gemcitabine3
iGMDRD781Sirolimus2
iGMDRD237ABT-7514
iGMDRD61Kinetin riboside1
iGMDRD351GW843682X3
iGMDRD341Triacsin c2
iGMDRD446LY 21832402
iGMDRD123Isoevodiamine2
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT4

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