FLT4
Summary: This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fms related tyrosine kinase 4 | MIM:136352 | Ensembl:ENSG00000037280 | HGNC:HGNC:3767 | PA28183 | 5q35.3 |
GO terms in FLT4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IMP | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | IDA | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | IMP | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IDA | GO:0036328 | VEGF-C-activated receptor activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| BP | IBA | GO:0001570 | vasculogenesis |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | ISS | GO:0001944 | vasculature development |
| BP | ISS | GO:0001945 | lymph vessel development |
| BP | IMP | GO:0001946 | lymphangiogenesis |
| BP | ISS | GO:0001946 | lymphangiogenesis |
| BP | IBA | GO:0002040 | sprouting angiogenesis |
| BP | ISS | GO:0002040 | sprouting angiogenesis |
| BP | IEA | GO:0003016 | respiratory system process |
| BP | TAS | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IMP | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IDA | GO:0038084 | vascular endothelial growth factor signaling pathway |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IGI | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0048286 | lung alveolus development |
| BP | ISS | GO:0048514 | blood vessel morphogenesis |
| BP | ISS | GO:0060312 | regulation of blood vessel remodeling |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0090037 | positive regulation of protein kinase C signaling |
Gene expression in normal tissue: FLT4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLT4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | vegf_vegfr_pathway | VEGF and VEGFR signaling network |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194313 | VEGF ligand-receptor interactions |
| reactome | R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLT4
CLASSFICATION
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