HOXC11
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox C11 | MIM:605559 | Ensembl:ENSG00000123388 | HGNC:HGNC:5123 | PA29398 | 12q13.13 |
GO terms in HOXC11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0001656 | metanephros development |
| BP | IEA | GO:0001759 | organ induction |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007492 | endoderm development |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | IEA | GO:0042733 | embryonic digit morphogenesis |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060272 | embryonic skeletal joint morphogenesis |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
Gene expression in normal tissue: HOXC11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXC11
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