HSPB1
Summary: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602195 Ensembl IDEnsembl:ENSG00000106211 HGNC IDHGNC:HGNC:5246 PHARMGKB IDPA29511 Map Location7q11.23 | |||||
GO terms in HSPB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | ISS | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008426 | protein kinase C inhibitor activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IMP | GO:0042802 | identical protein binding |
Gene expression in normal tissue: HSPB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | mta3pathway | downregulated of mta-3 in er-negative breast tumors |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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