HSPB1
Summary: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family B (small) member 1 | MIM:602195 | Ensembl:ENSG00000106211 | HGNC:HGNC:5246 | PA29511 | 7q11.23 |
GO terms in HSPB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | ISS | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008426 | protein kinase C inhibitor activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IMP | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0043130 | ubiquitin binding |
| MF | IMP | GO:0044183 | protein binding involved in protein folding |
| CC | ISS | GO:0000502 | proteasome complex |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0030018 | Z disc |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:1904115 | axon cytoplasm |
| BP | HEP | GO:0001895 | retina homeostasis |
| BP | IMP | GO:0001932 | regulation of protein phosphorylation |
| BP | TAS | GO:0006446 | regulation of translational initiation |
| BP | ISS | GO:0006469 | negative regulation of protein kinase activity |
| BP | NAS | GO:0006986 | response to unfolded protein |
| BP | IEP | GO:0009615 | response to virus |
| BP | NAS | GO:0010506 | regulation of autophagy |
| BP | ISS | GO:0032731 | positive regulation of interleukin-1 beta production |
| BP | IMP | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0061077 | chaperone-mediated protein folding |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IEA | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:0099641 | anterograde axonal protein transport |
| BP | ISS | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001028 | positive regulation of endothelial cell chemotaxis |
Gene expression in normal tissue: HSPB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | mta3pathway | downregulated of mta-3 in er-negative breast tumors |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3395 | Cellular response to heat stress |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD227 | Fatostatin A | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD151 | CHM-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPB1
CLASSFICATION
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