Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

TGF-beta activated kinase 1 (MAP3K7) binding protein 1MIM:602615Ensembl:ENSG00000100324HGNC:HGNC:18157PA3060422q13.1

GO terms in TAB1

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000185activation of MAPKKK activity
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0001701in utero embryonic development
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0002755MyD88-dependent toll-like receptor signaling pathway
BPIEAGO:0003007heart morphogenesis
BPIEAGO:0003279cardiac septum development
BPIEAGO:0006470protein dephosphorylation
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007254JNK cascade
BPTASGO:0016579protein deubiquitination
BPIEAGO:0030324lung development
BPIEAGO:0035904aorta development
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0060976coronary vasculature development
BPTASGO:0070423nucleotide-binding oligomerization domain containing signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
CCTASGO:0010008endosome membrane
CCIDAGO:0016607nuclear speck
CCIEAGO:0032991protein-containing complex
MFIEAGO:0004722protein serine/threonine phosphatase activity
MFIPIGO:0005515protein binding
MFTASGO:0008047enzyme activator activity
MFIEAGO:0019209kinase activator activity
MFIEAGO:0044877protein-containing complex binding
MFIEAGO:0048273mitogen-activated protein kinase p38 binding

Gene expression in normal tissue: TAB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAB1

DatabasePathway IDPathway Des.
pidbmppathwayBMP receptor signaling
pidcmyb_pathwayC-MYB transcription factor network
pidil1pathwayIL1-mediated signaling events
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidtgfbrpathwayTGF-beta receptor signaling
pidtnfpathwayTNF receptor signaling pathway
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3851TLR4 Signaling and Tolerance
wikipathwaysWP75Toll-like Receptor Signaling Pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complex
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937042IRAK2 mediated activation of TAK1 complex
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complex
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocartail1rpathwaysignal transduction through il1r
biocartanfkbpathwaynf-kb signaling pathway
biocartatgfbpathwaytgf beta signaling pathway
biocartatollpathwaytoll-like receptor pathway
biocartawntpathwaywnt signaling pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD297Austocystin D3
iGMDRD446LY 21832403
iGMDRD730Kahalalide F3
iGMDRD286Nsc 6328393

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAB1