TAB1
Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602615 Ensembl IDEnsembl:ENSG00000100324 HGNC IDHGNC:HGNC:18157 PHARMGKB IDPA30604 Map Location22q13.1 | |||||
GO terms in TAB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IEA | GO:0003007 | heart morphogenesis |
Gene expression in normal tissue: TAB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | bmppathway | BMP receptor signaling |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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