ARHGEF10


Summary: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

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Name
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Ensembl ID
HGNC ID
PHARMGKB ID
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GO terms in ARHGEF10


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0022011 myelination in peripheral nervous system
BP IBA GO:0030036 actin cytoskeleton organization
BP IEA GO:0035023 regulation of Rho protein signal transduction
BP IMP GO:0051298 centrosome duplication
BP IBA GO:0051496 positive regulation of stress fiber assembly
BP IMP GO:0051496 positive regulation of stress fiber assembly
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Gene expression in normal tissue: ARHGEF10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGEF10


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Database
Pathway ID
Pathway Des.
pid rhoa_reg_pathway Regulation of RhoA activity
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-193648 NRAGE signals death through JNK
reactome R-HSA-193704 p75 NTR receptor-mediated signalling
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194840 Rho GTPase cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD511 CHEMBL399379 4
iGMDRD132 (-)-gallocatechin-3-O-gallate 3
iGMDRD123 Isoevodiamine 6
iGMDRD237 ABT-751 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGEF10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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