ARHGEF10
Summary: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:608136 Ensembl IDEnsembl:ENSG00000104728 HGNC IDHGNC:HGNC:14103 PHARMGKB IDPA24967 Map Location8p23.3 |
GO terms in ARHGEF10
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IMP | GO:0022011 | myelination in peripheral nervous system |
BP | IBA | GO:0030036 | actin cytoskeleton organization |
BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
BP | IMP | GO:0051298 | centrosome duplication |
BP | IBA | GO:0051496 | positive regulation of stress fiber assembly |
BP | IMP | GO:0051496 | positive regulation of stress fiber assembly |
Gene expression in normal tissue: ARHGEF10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGEF10
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Database | Pathway ID | Pathway Des. |
---|---|---|
pid | rhoa_reg_pathway | Regulation of RhoA activity |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-193648 | NRAGE signals death through JNK |
reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-194840 | Rho GTPase cycle |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGEF10
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |