ARHGEF10
Summary: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho guanine nucleotide exchange factor 10 | MIM:608136 | Ensembl:ENSG00000104728 | HGNC:HGNC:14103 | PA24967 | 8p23.3 |
GO terms in ARHGEF10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0022011 | myelination in peripheral nervous system |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IMP | GO:0051298 | centrosome duplication |
| BP | IBA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IMP | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IMP | GO:0090307 | mitotic spindle assembly |
| BP | IDA | GO:0090630 | activation of GTPase activity |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | NAS | GO:0005829 | cytosol |
| MF | IBA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IDA | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019894 | kinesin binding |
Gene expression in normal tissue: ARHGEF10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGEF10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD511 | CHEMBL399379 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD701 | NVP-AUY922 | 5 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD229 | B02 | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD255 | SB225002 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGEF10
CLASSFICATION
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