EIF3H
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 3 subunit H | MIM:603912 | Ensembl:ENSG00000147677 | HGNC:HGNC:3273 | PA162384854 | 8q23.3-q24.11 |
GO terms in EIF3H
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IC | GO:0006413 | translational initiation |
| BP | IDA | GO:0006413 | translational initiation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006446 | regulation of translational initiation |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | IDA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016282 | eukaryotic 43S preinitiation complex |
| CC | IBA | GO:0042788 | polysomal ribosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003743 | translation initiation factor activity |
| MF | IC | GO:0003743 | translation initiation factor activity |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008237 | metallopeptidase activity |
Gene expression in normal tissue: EIF3H
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF3H
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| wikipathways | WP107 | Translation Factors |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD144 | NSC95397 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF3H
CLASSFICATION
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