RPS6KA4
Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase A4 | MIM:603606 | Ensembl:ENSG00000162302 | HGNC:HGNC:10433 | PA34848 | 11q13.1 |
GO terms in RPS6KA4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| BP | TAS | GO:0001818 | negative regulation of cytokine production |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0016572 | histone phosphorylation |
| BP | TAS | GO:0032793 | positive regulation of CREB transcription factor activity |
| BP | IMP | GO:0033129 | positive regulation of histone phosphorylation |
| BP | IMP | GO:0035066 | positive regulation of histone acetylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0043987 | histone H3-S10 phosphorylation |
| BP | IMP | GO:0043988 | histone H3-S28 phosphorylation |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0070498 | interleukin-1-mediated signaling pathway |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: RPS6KA4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KA4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD103 | SN-38 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KA4
CLASSFICATION
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