RPS6KA4

Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribosomal protein S6 kinase A4
OMIM IDMIM:603606
Ensembl IDEnsembl:ENSG00000162302
HGNC IDHGNC:HGNC:10433
PHARMGKB IDPA34848
Map Location11q13.1

GO terms in RPS6KA4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IMP GO:0004674 protein serine/threonine kinase activity
MF NAS GO:0004711 ribosomal protein S6 kinase activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: RPS6KA4

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

undefined2DNA replication1ERK MAPK signaling1

Pathways in RPS6KA4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-373760 L1CAM interactions
reactome R-HSA-422475 Axon guidance
reactome R-HSA-437239 Recycling pathway of L1
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD634 SCHEMBL2608041 3
iGMDRD353 PD0325901 1
iGMDRD872 BRD7137 3
iGMDRD103 SN-38 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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