NFKBIA
Summary: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NFKB inhibitor alpha | MIM:164008 | Ensembl:ENSG00000100906 | HGNC:HGNC:7797 | PA31601 | 14q13.2 |
GO terms in NFKBIA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008139 | nuclear localization sequence binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IDA | GO:0051059 | NF-kappaB binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0033256 | I-kappaB/NF-kappaB complex |
| BP | IEA | GO:0000060 | protein import into nucleus, translocation |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0007253 | cytoplasmic sequestering of NF-kappaB |
| BP | IMP | GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| BP | IMP | GO:0010875 | positive regulation of cholesterol efflux |
| BP | IMP | GO:0010888 | negative regulation of lipid storage |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IEA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0032270 | positive regulation of cellular protein metabolic process |
| BP | IEA | GO:0032495 | response to muramyl dipeptide |
| BP | IDA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0034142 | toll-like receptor 4 signaling pathway |
| BP | IEA | GO:0035994 | response to muscle stretch |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0042994 | cytoplasmic sequestering of transcription factor |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043330 | response to exogenous dsRNA |
| BP | NAS | GO:0043392 | negative regulation of DNA binding |
| BP | IEA | GO:0045638 | negative regulation of myeloid cell differentiation |
| BP | IEA | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050729 | positive regulation of inflammatory response |
| BP | NAS | GO:0070417 | cellular response to cold |
| BP | IEA | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway |
| BP | IEA | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | NAS | GO:1901222 | regulation of NIK/NF-kappaB signaling |
Gene expression in normal tissue: NFKBIA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFKBIA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | il23pathway | IL23-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TSLP | TSLP |
| netpath | Pathway_TWEAK | TWEAK |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cd40pathway | cd40l signaling pathway |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | eponfkbpathway | erythropoietin mediated neuroprotection through nf-kb |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | ranklpathway | bone remodeling |
| biocarta | relapathway | acetylation and deacetylation of rela in nucleus |
| biocarta | rnapathway | double stranded rna induced gene expression |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tidpathway | chaperones modulate interferon signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-4755510 | SUMOylation of immune response proteins |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5603029 | IkBA variant leads to EDA-ID |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD662 | JQ-1 | 5 |
| iGMDRD300 | Tozasertib | 10 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD322 | FK 866 | 10 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD435 | BI-2536 | 5 |
| iGMDRD883 | CIL55A | 10 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD484 | Pluripotin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFKBIA
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.