STAG2
Summary: The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| stromal antigen 2 | MIM:300826 | Ensembl:ENSG00000101972 | HGNC:HGNC:11355 | PA36177 | Xq25 |
GO terms in STAG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0000775 | chromosome, centromeric region |
| CC | IDA | GO:0000785 | chromatin |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005694 | chromosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0008278 | cohesin complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0097431 | mitotic spindle pole |
| BP | IMP | GO:0007062 | sister chromatid cohesion |
| BP | IMP | GO:0032876 | negative regulation of DNA endoreduplication |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
| BP | IMP | GO:1901673 | regulation of mitotic spindle assembly |
Gene expression in normal tissue: STAG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2468052 | Establishment of Sister Chromatid Cohesion |
| reactome | R-HSA-2470946 | Cohesin Loading onto Chromatin |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68884 | Mitotic Telophase/Cytokinesis |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| pid | plk1_pathway | PLK1 signaling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD507 | GSK690693 | 1 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD971 | PARP inhibitor | 2 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD317 | CCT 018159 | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD400 | A-443654 | 1 |
| iGMDRD378 | ZM-447439 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAG2
CLASSFICATION
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