STAG2

Summary: The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namestromal antigen 2
OMIM IDMIM:300826
Ensembl IDEnsembl:ENSG00000101972
HGNC IDHGNC:HGNC:11355
PHARMGKB IDPA36177
Map LocationXq25

GO terms in STAG2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
CC TAS GO:0000775 chromosome, centromeric region
CC IDA GO:0000785 chromatin
CC TAS GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC TAS GO:0005694 chromosome
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Gene expression in normal tissue: STAG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

PI3K/MTOR signaling2undefined2Mitosis1Cell cycle1Genome integrity1RTK signaling1Protein stability and degradation1

Pathways in STAG2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1221632 Meiotic synapsis
reactome R-HSA-1474165 Reproduction
reactome R-HSA-1500620 Meiosis
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-1640170 Cell Cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD507 GSK690693 1
iGMDRD672 Alectinib 1
iGMDRD971 PARP inhibitor 2
iGMDRD532 Olaparib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAG2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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