iGMDRD400

Canonical SMILES: CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OCC(CC4=CNC5=CC=CC=C54)N

InChI: InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1

InChI Key: YWTBGJGMTBHQTM-IBGZPJMESA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameA-443654
CHEMBLCHEMBL379300
Pubchem CID10172900
DRUGBANK IDDB08073
Drug StatusAlone
Drug TypeSmall Molecule


Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 8

Drug-gene pathway enrichments

5reactome: Metabolism of proteins4reactome: Disease4reactome: Signal Transduction3kegg: Cell cycle - Homo sapiens (human)3reactome: Post-translational protein modification3reactome: Diseases of signal transduction3kegg: Pathways in cancer - Homo sapiens (human)3reactome: Gene expression (Transcription)3reactome: Generic Transcription Pathway3reactome: Cell Cycle

Drug-gene GO enrichments

9CC: nucleus7MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding6BP: positive regulation of transcription by RNA polymerase II6MF: protein binding5CC: cytoplasm5CC: cytosol5BP: negative regulation of transcription by RNA polymerase II4BP: fibroblast growth factor receptor signaling pathway4CC: nucleoplasm4BP: positive regulation of cell proliferation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1029 CDKN2A 1
2263 FGFR2 1
162979 ZNF296 2
4089 SMAD4 1
Showing 1 to 4 of 7 rows

Gene in drug-gene network: Network Plot

Models in A-443654

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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