EIF3A
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 3 subunit A | MIM:602039 | Ensembl:ENSG00000107581 | HGNC:HGNC:3271 | PA27699 | 10q26.11 |
GO terms in EIF3A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0001732 | formation of cytoplasmic translation initiation complex |
| BP | IDA | GO:0001732 | formation of cytoplasmic translation initiation complex |
| BP | IBA | GO:0002188 | translation reinitiation |
| BP | IC | GO:0006413 | translational initiation |
| BP | TAS | GO:0006413 | translational initiation |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0075522 | IRES-dependent viral translational initiation |
| BP | IDA | GO:0075525 | viral translational termination-reinitiation |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| CC | IEA | GO:0005874 | microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0043614 | multi-eIF complex |
| CC | IBA | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e |
| CC | IBA | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003743 | translation initiation factor activity |
| MF | IC | GO:0003743 | translation initiation factor activity |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | NAS | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
Gene expression in normal tissue: EIF3A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF3A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| biocarta | eifpathway | eukaryotic protein translation |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD202 | Curcumin | 9 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF3A
CLASSFICATION
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