SEMA3B


Summary: The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
semaphorin 3BMIM:601281Ensembl:ENSG00000012171HGNC:HGNC:10724PA356463p21.31

GO terms in SEMA3B


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0030215semaphorin receptor binding
MFIBAGO:0038191neuropilin binding
MFIBAGO:0045499chemorepellent activity
MFTASGO:0045499chemorepellent activity
CCIBAGO:0005615extracellular space
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005887integral component of plasma membrane
BPIBAGO:0001755neural crest cell migration
BPTASGO:0007267cell-cell signaling
BPTASGO:0007411axon guidance
BPIBAGO:0030335positive regulation of cell migration
BPIBAGO:0048843negative regulation of axon extension involved in axon guidance
BPIBAGO:0050919negative chemotaxis
BPTASGO:0061643chemorepulsion of axon
BPIBAGO:0071526semaphorin-plexin signaling pathway

Gene expression in normal tissue: SEMA3B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEMA3B


DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1008SR-II-138A2
iGMDRD512nutlin 35
iGMDRD405PIK-754
iGMDRD193Fqi12
iGMDRD446LY 21832402
iGMDRD341Triacsin c2
iGMDRD945ML2141
iGMDRD154NSC237662
iGMDRD466Chaetocin4
iGMDRD137Indisulam2
iGMDRD121GMX17784
iGMDRD138PX 122
iGMDRD267Oligomycin A1
iGMDRD105Triptolide1
iGMDRD289Parthenolide5
iGMDRD562Navitoclax3
iGMDRD398Sepantronium2
iGMDRD872BRD71372
iGMDRD188Piperlongumine5
iGMDRD286Nsc 6328391
iGMDRD871BRD63684
iGMDRD367Ro 28-16752
iGMDRD322FK 8665
iGMDRD64Parbendazole2
iGMDRD147Prima-11
iGMDRD246NPC262

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEMA3B

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