SEMA3B
Summary: The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| semaphorin 3B | MIM:601281 | Ensembl:ENSG00000012171 | HGNC:HGNC:10724 | PA35646 | 3p21.31 |
GO terms in SEMA3B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0030215 | semaphorin receptor binding |
| MF | IBA | GO:0038191 | neuropilin binding |
| MF | IBA | GO:0045499 | chemorepellent activity |
| MF | TAS | GO:0045499 | chemorepellent activity |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IBA | GO:0001755 | neural crest cell migration |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IBA | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0048843 | negative regulation of axon extension involved in axon guidance |
| BP | IBA | GO:0050919 | negative chemotaxis |
| BP | TAS | GO:0061643 | chemorepulsion of axon |
| BP | IBA | GO:0071526 | semaphorin-plexin signaling pathway |
Gene expression in normal tissue: SEMA3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEMA3B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD246 | NPC26 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEMA3B
CLASSFICATION
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