NEK8


Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
NIMA related kinase 8MIM:609799Ensembl:ENSG00000160602HGNC:HGNC:13387PA3836117q11.2

GO terms in NEK8


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
CCIBAGO:0005813centrosome
CCIEAGO:0005856cytoskeleton
CCIMPGO:0005929cilium
CCISSGO:0005929cilium
CCIEAGO:0097543ciliary inversin compartment
CCIEAGO:0097546ciliary base
BPIEAGO:0006468protein phosphorylation
BPIBAGO:0007059chromosome segregation
BPIEAGO:0007368determination of left/right symmetry
BPIEAGO:0007507heart development
BPIMPGO:0009887animal organ morphogenesis
BPIDAGO:0035330regulation of hippo signaling
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: NEK8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEK8


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD366PI-1032
iGMDRD269Purmorphamine2
iGMDRD329Merck602
iGMDRD263AACOCF32
iGMDRD300Tozasertib2
iGMDRD434BMS-5369244
iGMDRD705Nakiterpiosin1
iGMDRD105Triptolide2
iGMDRD6AM-5803
iGMDRD481Dactolisib1
iGMDRD85Ursolic acid2
iGMDRD237ABT-7513
iGMDRD351GW843682X1
iGMDRD154NSC237664
iGMDRD945ML2141
iGMDRD424Tamatinib4
iGMDRD116CD4371
iGMDRD405PIK-752
iGMDRD399Selumetinib2
iGMDRD780PP-301
iGMDRD506Fedratinib1
iGMDRD577BIX012942
iGMDRD64Parbendazole3
iGMDRD369TGX-1152
iGMDRD524ISX-91
iGMDRD255SB2250022
iGMDRD294Batimastat1
iGMDRD446LY 21832403
iGMDRD193Fqi13
iGMDRD151CHM-13
iGMDRD554CHEMBL14341371
iGMDRD579PF7502
iGMDRD546BMS-7548071

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK8

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