NEK8
Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 8 | MIM:609799 | Ensembl:ENSG00000160602 | HGNC:HGNC:13387 | PA38361 | 17q11.2 |
GO terms in NEK8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IMP | GO:0005929 | cilium |
| CC | ISS | GO:0005929 | cilium |
| CC | IEA | GO:0097543 | ciliary inversin compartment |
| CC | IEA | GO:0097546 | ciliary base |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007059 | chromosome segregation |
| BP | IEA | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0007507 | heart development |
| BP | IMP | GO:0009887 | animal organ morphogenesis |
| BP | IDA | GO:0035330 | regulation of hippo signaling |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NEK8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK8
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 2 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD546 | BMS-754807 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK8
CLASSFICATION
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