ELF4


Summary: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
E74 like ETS transcription factor 4MIM:300775Ensembl:ENSG00000102034HGNC:HGNC:3319PA27747Xq26.1

GO terms in ELF4


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0005515protein binding
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0016604nuclear body
CCIDAGO:0016605PML body
BPISSGO:0001787natural killer cell proliferation
BPISSGO:0001866NK T cell proliferation
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIBAGO:0030154cell differentiation
BPIEAGO:0045087innate immune response
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: ELF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ELF4


DatabasePathway IDPathway Des.
wikipathwaysWP3945TYROBP Causal Network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide3
iGMDRD171Pemetrexed3
iGMDRD52Rotenone6
iGMDRD187BRD98766
iGMDRD662JQ-13
iGMDRD300Tozasertib2
iGMDRD268Cerulenin3
iGMDRD330BRD41326
iGMDRD599Salermide3
iGMDRD494Neopeltolide4
iGMDRD483SCH-5290743
iGMDRD405PIK-751
iGMDRD341Triacsin c4
iGMDRD85Ursolic acid1
iGMDRD193Fqi11
iGMDRD61Kinetin riboside4
iGMDRD297Austocystin D2
iGMDRD466Chaetocin3
iGMDRD154NSC237663
iGMDRD132(-)-gallocatechin-3-O-gallate3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ELF4

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