ELF4
Summary: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| E74 like ETS transcription factor 4 | MIM:300775 | Ensembl:ENSG00000102034 | HGNC:HGNC:3319 | PA27747 | Xq26.1 |
GO terms in ELF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016605 | PML body |
| BP | ISS | GO:0001787 | natural killer cell proliferation |
| BP | ISS | GO:0001866 | NK T cell proliferation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: ELF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ELF4
CLASSFICATION
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