ELF4

Summary: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameE74 like ETS transcription factor 4
OMIM IDMIM:300775
Ensembl IDEnsembl:ENSG00000102034
HGNC IDHGNC:HGNC:3319
PHARMGKB IDPA27747
Map LocationXq26.1

GO terms in ELF4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
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Gene expression in normal tissue: ELF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15Chromatin other1Mitosis1Biosynthesis of secondary metabolites1One carbon pool by folate1Chromatin histone acetylation1

Pathways in ELF4


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Database
Pathway ID
Pathway Des.
wikipathways WP3945 TYROBP Causal Network
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD289 Parthenolide 3
iGMDRD171 Pemetrexed 3
iGMDRD52 Rotenone 6
iGMDRD187 BRD9876 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ELF4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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