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HSP90AA1

Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameheat shock protein 90 alpha family class A member 1 OMIM IDMIM:140571 Ensembl IDEnsembl:ENSG00000080824 HGNC IDHGNC:HGNC:5253 PHARMGKB IDPA29519 Map Location14q32.31

Gene Categories:

RNA DIRECTED DNA POLYMERASE KINASE TUMOR SUPPRESSOR DRUGGABLE GENOME TYROSINE KINASE

GO terms in HSP90AA1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000086	G2/M transition of mitotic cell cycle
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0006839	mitochondrial transport
BP	TAS	GO:0006898	receptor-mediated endocytosis
BP	NAS	GO:0006986	response to unfolded protein
BP	IDA	GO:0007004	telomere maintenance via telomerase

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Gene expression in normal tissue: HSP90AA1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSP90AA1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1227986	Signaling by ERBB2
reactome	R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	3
iGMDRD560	MK-2206	3
iGMDRD248	BRD4354	1
iGMDRD698	Neratinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSP90AA1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.