HSP90AA1
Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein 90 alpha family class A member 1 | MIM:140571 | Ensembl:ENSG00000080824 | HGNC:HGNC:5253 | PA29519 | 14q32.31 |
GO terms in HSP90AA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0006839 | mitochondrial transport |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | NAS | GO:0006986 | response to unfolded protein |
| BP | IDA | GO:0007004 | telomere maintenance via telomerase |
| BP | NAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0009408 | response to heat |
| BP | ISS | GO:0009409 | response to cold |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0021955 | central nervous system neuron axonogenesis |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | IDA | GO:0031396 | regulation of protein ubiquitination |
| BP | IDA | GO:0032273 | positive regulation of protein polymerization |
| BP | ISS | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0042026 | protein refolding |
| BP | NAS | GO:0043254 | regulation of protein complex assembly |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | NAS | GO:0043335 | protein unfolding |
| BP | IDA | GO:0045040 | protein import into mitochondrial outer membrane |
| BP | ISS | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | ISS | GO:0046677 | response to antibiotic |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0048675 | axon extension |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050999 | regulation of nitric-oxide synthase activity |
| BP | IDA | GO:0051131 | chaperone-mediated protein complex assembly |
| BP | TAS | GO:0051186 | cofactor metabolic process |
| BP | ISS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0051973 | positive regulation of telomerase activity |
| BP | TAS | GO:0061684 | chaperone-mediated autophagy |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IDA | GO:1902949 | positive regulation of tau-protein kinase activity |
| BP | IGI | GO:1903364 | positive regulation of cellular protein catabolic process |
| BP | ISS | GO:1903827 | regulation of cellular protein localization |
| BP | IDA | GO:1905323 | telomerase holoenzyme complex assembly |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | IEA | GO:0042470 | melanosome |
| CC | ISS | GO:0043025 | neuronal cell body |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | ISS | GO:0044294 | dendritic growth cone |
| CC | ISS | GO:0044295 | axonal growth cone |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:0071682 | endocytic vesicle lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| MF | TAS | GO:0000166 | nucleotide binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | TAS | GO:0005524 | ATP binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | HDA | GO:0023026 | MHC class II protein complex binding |
| MF | IDA | GO:0030235 | nitric-oxide synthase regulator activity |
| MF | IDA | GO:0030911 | TPR domain binding |
| MF | TAS | GO:0030911 | TPR domain binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | TAS | GO:0042623 | ATPase activity, coupled |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0048156 | tau protein binding |
| MF | IPI | GO:0051020 | GTPase binding |
| MF | IEA | GO:0051082 | unfolded protein binding |
| MF | IPI | GO:0070182 | DNA polymerase binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
| MF | IPI | GO:1990782 | protein tyrosine kinase binding |
Gene expression in normal tissue: HSP90AA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSP90AA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-192905 | vRNP Assembly |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-202131 | Metabolism of nitric oxide |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-203615 | eNOS activation |
| reactome | R-HSA-203765 | eNOS activation and regulation |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-3000484 | Scavenging by Class F Receptors |
| reactome | R-HSA-3000484 | Scavenging by Class F Receptors |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-3371511 | HSF1 activation |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371568 | Attenuation phase |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-399954 | Sema3A PAK dependent Axon repulsion |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-5336415 | Uptake and function of diphtheria toxin |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8978934 | Metabolism of cofactors |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| biocarta | ahrpathway | ahr signal transduction pathway |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | arfpathway | tumor suppressor arf inhibits ribosomal biogenesis |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | hif1apathway | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| pharmgkb | PA2027 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics |
| smpdb | SMP00441 | Prednisolone Action Pathway |
| smpdb | SMP00632 | Prednisolone Metabolism Pathway |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD229 | B02 | 1 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD554 | CHEMBL1434137 | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD640 | CAY10618 | 2 |
| iGMDRD369 | TGX-115 | 4 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSP90AA1
CLASSFICATION
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