HSP90AA1
Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:140571 Ensembl IDEnsembl:ENSG00000080824 HGNC IDHGNC:HGNC:5253 PHARMGKB IDPA29519 Map Location14q32.31 |
GO terms in HSP90AA1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
BP | TAS | GO:0006839 | mitochondrial transport |
BP | TAS | GO:0006898 | receptor-mediated endocytosis |
BP | NAS | GO:0006986 | response to unfolded protein |
BP | IDA | GO:0007004 | telomere maintenance via telomerase |
Gene expression in normal tissue: HSP90AA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSP90AA1
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1227986 | Signaling by ERBB2 |
reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in HSP90AA1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |