HSP90AA1


Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in HSP90AA1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
BP IDA GO:0001934 positive regulation of protein phosphorylation
BP TAS GO:0006839 mitochondrial transport
BP TAS GO:0006898 receptor-mediated endocytosis
BP NAS GO:0006986 response to unfolded protein
BP IDA GO:0007004 telomere maintenance via telomerase
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Gene expression in normal tissue: HSP90AA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSP90AA1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1227986 Signaling by ERBB2
reactome R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD405 PIK-75 3
iGMDRD560 MK-2206 3
iGMDRD248 BRD4354 1
iGMDRD698 Neratinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSP90AA1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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