HMMR


Summary: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
hyaluronan mediated motility receptorMIM:600936Ensembl:ENSG00000072571HGNC:HGNC:5012PA293405q34

GO terms in HMMR


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPTASGO:0030214hyaluronan catabolic process
CCIDAGO:0005813centrosome
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0009986cell surface
CCIDAGO:0015630microtubule cytoskeleton
CCHDAGO:0016020membrane
MFIPIGO:0005515protein binding

Gene expression in normal tissue: HMMR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMMR


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1630316Glycosaminoglycan metabolism
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-2142845Hyaluronan metabolism
reactomeR-HSA-2160916Hyaluronan uptake and degradation
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-8854518AURKA Activation by TPX2
kegghsa04512ECM-receptor interaction - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369242
iGMDRD137Indisulam1
iGMDRD121GMX17782
iGMDRD451Serdemetan2
iGMDRD42Vorinostat3
iGMDRD562Navitoclax4
iGMDRD329Merck605
iGMDRD577BIX012942
iGMDRD506Fedratinib5
iGMDRD414MST-3122
iGMDRD871BRD63683
iGMDRD188Piperlongumine2
iGMDRD405PIK-754
iGMDRD546BMS-7548072
iGMDRD866BRD18121
iGMDRD126Tipifarnib3
iGMDRD634SCHEMBL26080412
iGMDRD679Bistramide A5
iGMDRD280CYTOCHALASIN B2
iGMDRD297Austocystin D5
iGMDRD351GW843682X2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMMR

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