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HMMR

Summary: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namehyaluronan mediated motility receptor OMIM IDMIM:600936 Ensembl IDEnsembl:ENSG00000072571 HGNC IDHGNC:HGNC:5012 PHARMGKB IDPA29340 Map Location5q34

Gene Categories:

DRUGGABLE GENOME CELL SURFACE TUMOR SUPPRESSOR

GO terms in HMMR

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0010389	regulation of G2/M transition of mitotic cell cycle
BP	TAS	GO:0030214	hyaluronan catabolic process
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005886	plasma membrane

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Gene expression in normal tissue: HMMR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMMR

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1630316	Glycosaminoglycan metabolism
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-2142845	Hyaluronan metabolism
reactome	R-HSA-2160916	Hyaluronan uptake and degradation
reactome	R-HSA-453274	Mitotic G2-G2/M phases

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD434	BMS-536924	2
iGMDRD137	Indisulam	1
iGMDRD121	GMX1778	2
iGMDRD451	Serdemetan	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMMR

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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