CCNA2
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin A2 | MIM:123835 | Ensembl:ENSG00000145386 | HGNC:HGNC:1578 | PA94 | 4q27 |
GO terms in CCNA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IEA | GO:0001939 | female pronucleus |
| CC | IEA | GO:0001940 | male pronucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0097124 | cyclin A2-CDK2 complex |
| CC | IDA | GO:0097124 | cyclin A2-CDK2 complex |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEP | GO:0007265 | Ras protein signal transduction |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016572 | histone phosphorylation |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0033762 | response to glucagon |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IEA | GO:0044320 | cellular response to leptin stimulus |
| BP | IDA | GO:0044843 | cell cycle G1/S phase transition |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0071314 | cellular response to cocaine |
| BP | IEA | GO:0071373 | cellular response to luteinizing hormone stimulus |
| BP | IEA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071732 | cellular response to nitric oxide |
| BP | IEA | GO:0090102 | cochlea development |
| BP | IEA | GO:1990314 | cellular response to insulin-like growth factor stimulus |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0097472 | cyclin-dependent protein kinase activity |
Gene expression in normal tissue: CCNA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | atr_pathway | ATR signaling pathway |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | p53regulationpathway | p53 pathway |
| pid | p73pathway | p73 transcription factor network |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-170145 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-68911 | G2 Phase |
| reactome | R-HSA-68949 | Orc1 removal from chromatin |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69563 | p53-Dependent G1 DNA Damage Response |
| reactome | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD158 | NSC141540 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNA2
CLASSFICATION
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