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CCNA2

Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecyclin A2 OMIM IDMIM:123835 Ensembl IDEnsembl:ENSG00000145386 HGNC IDHGNC:HGNC:1578 PHARMGKB IDPA94 Map Location4q27

Gene Categories:

DRUGGABLE GENOME HISTONE MODIFICATION TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE

GO terms in CCNA2

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IDA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IEA	GO:0001939	female pronucleus
CC	IEA	GO:0001940	male pronucleus
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus

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Gene expression in normal tissue: CCNA2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNA2

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Database	Pathway ID	Pathway Des.
pid	atf2_pathway	ATF-2 transcription factor network
pid	atr_pathway	ATR signaling pathway
pid	e2f_pathway	E2F transcription factor network
pid	foxm1pathway	FOXM1 transcription factor network
pid	fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2
pid	il2_stat5pathway	IL2 signaling events mediated by STAT5

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	3
iGMDRD394	BX-795	2
iGMDRD546	BMS-754807	3
iGMDRD577	BIX01294	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNA2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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