NLRP6
Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NLR family pyrin domain containing 6 | MIM:609650 | Ensembl:ENSG00000174885 | HGNC:HGNC:22944 | PA162398002 | 11p15.5 |
Gene Categories:
G PROTEIN COUPLED RECEPTORGO terms in NLRP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0005000 | vasopressin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IEA | GO:0061702 | inflammasome complex |
| BP | IEA | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0009617 | response to bacterium |
| BP | IEA | GO:0009617 | response to bacterium |
| BP | IEA | GO:0010506 | regulation of autophagy |
| BP | IEA | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0070255 | regulation of mucus secretion |
| BP | IEA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: NLRP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLRP6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD60 | Quinoclamine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLRP6
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.