NLRP6
Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609650 Ensembl IDEnsembl:ENSG00000174885 HGNC IDHGNC:HGNC:22944 PHARMGKB IDPA162398002 Map Location11p15.5 | |||||
Gene Categories:
G PROTEIN COUPLED RECEPTORGO terms in NLRP6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0005000 | vasopressin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IEA | GO:0061702 | inflammasome complex |
| BP | IEA | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
Gene expression in normal tissue: NLRP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLRP6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLRP6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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