iGMDRD238


Canonical SMILES: CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

InChI: InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)

InChI Key: UXXQOJXBIDBUAC-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTandutinib
Pubchem CID3038520
DRUGBANK IDDB05465
Drug StatusAlone
Drug TypeSmall Molecule


Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Drug-gene pathway enrichments

1reactome: Generic Transcription Pathway1reactome: Metabolism of proteins1reactome: Deubiquitination1reactome: Signaling by BMP1reactome: Signal Transduction1wikipathways: ESC Pluripotency Pathways1wikipathways: Protein alkylation leading to liver fibrosis1wikipathways: TGF-beta Receptor Signaling1reactome: Ub-specific processing proteases1reactome: Post-translational protein modification

Drug-gene GO enrichments

4CC: nucleus4BP: BMP signaling pathway3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding2CC: cytoplasm2BP: SMAD protein signal transduction2BP: positive regulation of transcription by RNA polymerase II1BP: positive regulation of pri-miRNA transcription by RNA polymerase II1MF: RNA polymerase II proximal promoter sequence-specific DNA binding1BP: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus1BP: positive regulation of sprouting angiogenesis

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4086 SMAD1 1
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Gene in drug-gene network: Network Plot

Models in Tandutinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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