iGMDRD541

Canonical SMILES: CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C

InChI: InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)

InChI Key: ZFVRYNYOPQZKDG-UHFFFAOYSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameSNX-2112 (PF-04928473)
CHEMBLCHEMBL560895
Pubchem CID24772900
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

HSP90

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 2PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
80070 ADAMTS20 1
4170 MCL1 1
9757 KMT2B 1
7157 TP53 1
Showing 1 to 4 of 12 rows rows per page

Gene in drug-gene network: Network Plot

Models in SNX-2112 (PF-04928473)

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(ADAMTS20) gene CTRP undefined PANCAN SNX-2112 unresponsive in vitro
EXP(4EBP1_pS65) protein MCLP LUNG undefined SNX.2112 resistance in vitro
EXP(4EBP1_pT70) protein MCLP LUNG undefined SNX.2112 resistance in vitro
EXP(ANNEXINVII) protein MCLP PANCREAS undefined SNX.2112 sensitivity in vitro
EXP(MCL1) protein MCLP BOWEL undefined SNX.2112 resistance in vitro
EXP(SMAD1) protein MCLP undefined PANCAN SNX.2112 resistance in vitro
EXP(1433BETA) protein MCLP undefined PANCAN SNX.2112 sensitivity in vitro
EXP(ACVRL1) protein MCLP undefined PANCAN SNX.2112 sensitivity in vitro
EXP(TYRO3) protein MCLP undefined PANCAN SNX.2112 sensitivity in vitro
AMP(CHD9,CYLD) gene GDSC undefined PANCAN SNX-2112 resistance in vitro
Showing 1 to 10 of 14 rows rows per page

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.