iGMDRD392

Canonical SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

InChI: InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)

InChI Key: WJEOLQLKVOPQFV-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameMasitinib
CHEMBLCHEMBL1908391
Pubchem CID10074600
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

KITPDGFRAPDGFRB

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 12LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

7reactome: Signal Transduction6reactome: Gene expression (Transcription)6reactome: RNA Polymerase II Transcription5reactome: Generic Transcription Pathway4wikipathways: miR-targeted genes in lymphocytes - TarBase3reactome: TCF dependent signaling in response to WNT3kegg: Hepatocellular carcinoma - Homo sapiens (human)3reactome: Signaling by WNT3kegg: Thermogenesis - Homo sapiens (human)3kegg: PI3K-Akt signaling pathway - Homo sapiens (human)

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
8289 ARID1A 1
4170 MCL1 1
55252 ASXL2 1
7307 U2AF1 1
Showing 1 to 4 of 11 rows rows per page

Gene in drug-gene network: Network Plot

Models in Masitinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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