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SOX17

Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
SRY-box 17	MIM:610928	Ensembl:ENSG00000164736	HGNC:HGNC:18122	PA38296	8q11.23

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE

GO terms in SOX17

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IBA	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IEA	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	ISS	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MF	IEA	GO:0003713	transcription coactivator activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008013	beta-catenin binding
MF	IPI	GO:0008134	transcription factor binding
MF	IEA	GO:0043565	sequence-specific DNA binding
MF	ISS	GO:0044212	transcription regulatory region DNA binding
MF	IEA	GO:0046982	protein heterodimerization activity
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005667	transcription factor complex
CC	IBA	GO:0044798	nuclear transcription factor complex
CC	IEA	GO:0044798	nuclear transcription factor complex
BP	IBA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IBA	GO:0001525	angiogenesis
BP	ISS	GO:0001525	angiogenesis
BP	IBA	GO:0001568	blood vessel development
BP	IBA	GO:0001570	vasculogenesis
BP	ISS	GO:0001570	vasculogenesis
BP	IDA	GO:0001706	endoderm formation
BP	IEA	GO:0001828	inner cell mass cellular morphogenesis
BP	ISS	GO:0001947	heart looping
BP	ISS	GO:0003142	cardiogenic plate morphogenesis
BP	ISS	GO:0003143	embryonic heart tube morphogenesis
BP	ISS	GO:0003151	outflow tract morphogenesis
BP	IEA	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development
BP	IBA	GO:0006355	regulation of transcription, DNA-templated
BP	ISS	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0007283	spermatogenesis
BP	IEA	GO:0007493	endodermal cell fate determination
BP	IBA	GO:0007507	heart development
BP	IBA	GO:0009653	anatomical structure morphogenesis
BP	IEA	GO:0021903	rostrocaudal neural tube patterning
BP	IEA	GO:0023019	signal transduction involved in regulation of gene expression
BP	IBA	GO:0030154	cell differentiation
BP	IMP	GO:0030308	negative regulation of cell growth
BP	IMP	GO:0031648	protein destabilization
BP	ISS	GO:0035050	embryonic heart tube development
BP	IEA	GO:0042074	cell migration involved in gastrulation
BP	IEA	GO:0042662	negative regulation of mesodermal cell fate specification
BP	IDA	GO:0042789	mRNA transcription by RNA polymerase II
BP	IEA	GO:0045597	positive regulation of cell differentiation
BP	IEA	GO:0045732	positive regulation of protein catabolic process
BP	ISS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0045995	regulation of embryonic development
BP	ISS	GO:0048617	embryonic foregut morphogenesis
BP	IEA	GO:0048643	positive regulation of skeletal muscle tissue development
BP	IEA	GO:0048866	stem cell fate specification
BP	IMP	GO:0050821	protein stabilization
BP	IEA	GO:0060070	canonical Wnt signaling pathway
BP	ISS	GO:0060214	endocardium formation
BP	ISS	GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
BP	IMP	GO:0060913	cardiac cell fate determination
BP	TAS	GO:0060914	heart formation
BP	ISS	GO:0060956	endocardial cell differentiation
BP	IEA	GO:0061009	common bile duct development
BP	IEA	GO:0061010	gall bladder development
BP	ISS	GO:0061031	endodermal digestive tract morphogenesis
BP	IMP	GO:0072001	renal system development
BP	IEA	GO:0072091	regulation of stem cell proliferation
BP	IMP	GO:0090090	negative regulation of canonical Wnt signaling pathway
BP	IEA	GO:1990830	cellular response to leukemia inhibitory factor
BP	IEA	GO:2000035	regulation of stem cell division
BP	IEA	GO:2000043	regulation of cardiac cell fate specification

Gene expression in normal tissue: SOX17

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX17

Database	Pathway ID	Pathway Des.
wikipathways	WP2406	Cardiac Progenitor Differentiation
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2857	Mesodermal Commitment Pathway
wikipathways	WP428	Wnt Signaling Pathway
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-3769402	Deactivation of the beta-catenin transactivating complex

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD392	Masitinib	1
iGMDRD119	Temsirolimus	1
iGMDRD436	GSK429286A	1
iGMDRD218	XAV 939	1
iGMDRD454	JNK Inhibitor VIII	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX17

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.