SOX17


Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SRY-box 17MIM:610928Ensembl:ENSG00000164736HGNC:HGNC:18122PA382968q11.23

GO terms in SOX17


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFISSGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIEAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0008013beta-catenin binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0043565sequence-specific DNA binding
MFISSGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046982protein heterodimerization activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCIBAGO:0044798nuclear transcription factor complex
CCIEAGO:0044798nuclear transcription factor complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0001525angiogenesis
BPISSGO:0001525angiogenesis
BPIBAGO:0001568blood vessel development
BPIBAGO:0001570vasculogenesis
BPISSGO:0001570vasculogenesis
BPIDAGO:0001706endoderm formation
BPIEAGO:0001828inner cell mass cellular morphogenesis
BPISSGO:0001947heart looping
BPISSGO:0003142cardiogenic plate morphogenesis
BPISSGO:0003143embryonic heart tube morphogenesis
BPISSGO:0003151outflow tract morphogenesis
BPIEAGO:0003308negative regulation of Wnt signaling pathway involved in heart development
BPIBAGO:0006355regulation of transcription, DNA-templated
BPISSGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007493endodermal cell fate determination
BPIBAGO:0007507heart development
BPIBAGO:0009653anatomical structure morphogenesis
BPIEAGO:0021903rostrocaudal neural tube patterning
BPIEAGO:0023019signal transduction involved in regulation of gene expression
BPIBAGO:0030154cell differentiation
BPIMPGO:0030308negative regulation of cell growth
BPIMPGO:0031648protein destabilization
BPISSGO:0035050embryonic heart tube development
BPIEAGO:0042074cell migration involved in gastrulation
BPIEAGO:0042662negative regulation of mesodermal cell fate specification
BPIDAGO:0042789mRNA transcription by RNA polymerase II
BPIEAGO:0045597positive regulation of cell differentiation
BPIEAGO:0045732positive regulation of protein catabolic process
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045995regulation of embryonic development
BPISSGO:0048617embryonic foregut morphogenesis
BPIEAGO:0048643positive regulation of skeletal muscle tissue development
BPIEAGO:0048866stem cell fate specification
BPIMPGO:0050821protein stabilization
BPIEAGO:0060070canonical Wnt signaling pathway
BPISSGO:0060214endocardium formation
BPISSGO:0060807regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
BPIMPGO:0060913cardiac cell fate determination
BPTASGO:0060914heart formation
BPISSGO:0060956endocardial cell differentiation
BPIEAGO:0061009common bile duct development
BPIEAGO:0061010gall bladder development
BPISSGO:0061031endodermal digestive tract morphogenesis
BPIMPGO:0072001renal system development
BPIEAGO:0072091regulation of stem cell proliferation
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPIEAGO:2000035regulation of stem cell division
BPIEAGO:2000043regulation of cardiac cell fate specification

Gene expression in normal tissue: SOX17

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX17


DatabasePathway IDPathway Des.
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP428Wnt Signaling Pathway
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD392Masitinib1
iGMDRD119Temsirolimus1
iGMDRD436GSK429286A1
iGMDRD218XAV 9391
iGMDRD454JNK Inhibitor VIII1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX17

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