SOX17

Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSRY-box 17
OMIM IDMIM:610928
Ensembl IDEnsembl:ENSG00000164736
HGNC IDHGNC:HGNC:18122
PHARMGKB IDPA38296
Map Location8q11.23

GO terms in SOX17


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IBA GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF IEA GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Gene expression in normal tissue: SOX17

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1KIDNEtissue: KIDNE cancer: KIDNEY model num: 0KIDNEYtissue: KIDNEY cancer: Renal Clear Cell Carcinoma (CCRCC) model num: 2OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 2

Gene-drug pathway distribution

JNK and p38 signaling1WNT signaling1Cytoskeleton1PI3K/MTOR signaling1Other, kinases1

Pathways in SOX17


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Database
Pathway ID
Pathway Des.
wikipathways WP2406 Cardiac Progenitor Differentiation
wikipathways WP2853 Endoderm Differentiation
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP428 Wnt Signaling Pathway
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD392 Masitinib 1
iGMDRD119 Temsirolimus 1
iGMDRD436 GSK429286A 1
iGMDRD218 XAV 939 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX17

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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