iGMDRD535

Canonical SMILES: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5

InChI: InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33)

InChI Key: IASPBORHOMBZMY-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameSRT-1720
Pubchem CID24180100
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6

Drug-gene pathway enrichments

2reactome: Generic Transcription Pathway2reactome: Gene expression (Transcription)2reactome: Signal Transduction2reactome: RNA Polymerase II Transcription1kegg: Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)1kegg: Hippo signaling pathway - Homo sapiens (human)1kegg: TGF-beta signaling pathway - Homo sapiens (human)1kegg: Transcriptional misregulation in cancer - Homo sapiens (human)1wikipathways: Bone Morphogenic Protein (BMP) Signalling and Regulation1wikipathways: miR-targeted genes in lymphocytes - TarBase

Drug-gene GO enrichments

6CC: nucleus4BP: BMP signaling pathway4CC: cytosol4CC: cytoplasm3MF: protein binding3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3BP: negative regulation of TOR signaling2BP: negative regulation of cell proliferation2BP: protein stabilization2BP: SMAD protein signal transduction

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
8266 UBL4A 1
4086 SMAD1 1
7248 TSC1 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

PX 12PX 12tipifarnib-P2tipifarnib-P2neopeltolideneopeltolidecytochalasin.Bcytochalasin.BBIX01294BIX01294EverolimusEverolimusisoevodiamineisoevodiamineparbendazoleparbendazoleLY 2183240LY 2183240mTOR inhibitorsmTOR inhibitorsNsc 632839Nsc 632839indisulamindisulamFqi1Fqi1CHM-1CHM-1TSC1TSC1SMAD1SMAD1CAY10618CAY10618manumycin.Amanumycin.AML 210ML 210NSC95397NSC95397PRIMA-1PRIMA-1ML162ML162ceruleninceruleninPL.DIPL.DISepantroniumSepantroniumoligomycin.Aoligomycin.A17-AAG17-AAGnecrosulfonamidenecrosulfonamideDabrafenibDabrafenibmethylstatmethylstatX1S.3R.RSL.3X1S.3R.RSL.3erastinerastinBRD-K34222889BRD-K34222889UBL4AUBL4ASRT-1720SRT-1720

Models in SRT-1720

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(G6PD) protein MCLP LUNG undefined SRT.1720 sensitivity in vitro
EXP(SMAD1) protein MCLP undefined PANCAN SRT.1720 resistance in vitro
EXP(ANNEXINVII) protein MCLP undefined PANCAN SRT.1720 sensitivity in vitro
EXP(TRANSGLUTAMINASE) protein MCLP undefined PANCAN SRT.1720 sensitivity in vitro
EXP(TSC1) protein MCLP undefined PANCAN SRT.1720 sensitivity in vitro
EXP(CMET) protein MCLP undefined PANCAN SRT.1720 sensitivity in vitro
EXP(H2AX_pS140) protein MCLP undefined PANCAN SRT.1720 resistance in vitro
Showing 1 to 7 of 7 rows

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