iGMDRD340

Canonical SMILES: CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

InChI: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-

InChI Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameSU 11274
CHEMBLCHEMBL261641
Pubchem CID9549300
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

MET

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 7

Drug-gene pathway enrichments

3reactome: Signal Transduction3reactome: Disease2reactome: Cell Cycle Checkpoints2kegg: HTLV-I infection - Homo sapiens (human)2reactome: Cell Cycle2reactome: MAPK family signaling cascades1pharmgkb: Irinotecan Pathway, Pharmacokinetics1pharmgkb: Etoposide Pathway, Pharmacokinetics/Pharmacodynamics1kegg: Pentose and glucuronate interconversions - Homo sapiens (human)1pharmgkb: Acetaminophen Pathway, Pharmacokinetics

Drug-gene GO enrichments

5CC: nucleus5CC: cytoplasm3BP: positive regulation of ERK1 and ERK2 cascade3MF: platelet-derived growth factor beta-receptor activity3CC: intracellular membrane-bounded organelle3MF: protein binding3MF: platelet-derived growth factor binding3CC: membrane3CC: nucleoplasm3BP: protein export from nucleus

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
5159 PDGFRB 1
7158 TP53BP1 1
54658 UGT1A1 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in SU 11274

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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