iGMDRD340

Canonical SMILES: CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

InChI: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-

InChI Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameSU 11274
CHEMBLCHEMBL261641
Pubchem CID9549300
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

MET

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 7

Drug-gene pathway enrichments

3reactome: Signal Transduction3reactome: Disease2reactome: Cell Cycle Checkpoints2kegg: HTLV-I infection - Homo sapiens (human)2reactome: Cell Cycle2reactome: MAPK family signaling cascades1pharmgkb: Irinotecan Pathway, Pharmacokinetics1pharmgkb: Etoposide Pathway, Pharmacokinetics/Pharmacodynamics1kegg: Pentose and glucuronate interconversions - Homo sapiens (human)1pharmgkb: Acetaminophen Pathway, Pharmacokinetics

Drug-gene GO enrichments

5CC: nucleus5CC: cytoplasm3BP: positive regulation of ERK1 and ERK2 cascade3MF: platelet-derived growth factor beta-receptor activity3CC: intracellular membrane-bounded organelle3MF: protein binding3MF: platelet-derived growth factor binding3CC: membrane3CC: nucleoplasm3BP: protein export from nucleus

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
5159 PDGFRB 1
7158 TP53BP1 1
54658 UGT1A1 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

SMER3SMER3BIRB-796BIRB-796importazoleimportazolePL.DIPL.DIAM-580AM-580NilotinibNilotinibfingolimodfingolimodBelinostatBelinostaterastinerastinIrinotecanIrinotecanUGT1A1UGT1A1RITARITAnavitoclaxnavitoclaxcytochalasin.Bcytochalasin.BVER 155008VER 155008NSC95397NSC95397ABT737ABT737Merck60Merck60SepantroniumSepantroniumNsc 632839Nsc 632839SMR000068650SMR000068650ChloropentafluorobenzeneChloropentafluorobenzeneTP53BP1TP53BP1quinoclaminequinoclamineISX-9ISX-9BIX01294BIX01294BRD6368BRD6368leucascandrolide Aleucascandrolide AavrainvillamideavrainvillamideNPC26NPC26piperlonguminepiperlongumineBRD7137BRD7137PAC-1PAC-1PDGFRBPDGFRBtipifarnib-P2tipifarnib-P2BI-2536BI-2536GW-843682XGW-843682XAZD-1775AZD-1775PaclitaxelPaclitaxelGSK-461364GSK-461364XL-880XL-880PF 184PF 184XPO1XPO1SU 11274SU 11274

Models in SU 11274

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(53BP1) protein MCLP undefined PANCAN SU11274 resistance in vitro
EXP(ECADHERIN) protein MCLP undefined PANCAN SU11274 sensitivity in vitro
EXP(EGFR_pY1068) protein MCLP undefined PANCAN SU11274 sensitivity in vitro
EXP(TRANSGLUTAMINASE) protein MCLP undefined PANCAN SU11274 sensitivity in vitro
EXP(PDGFRB) protein MCLP undefined PANCAN SU11274 resistance in vitro
EXP(UGT1A) protein MCLP undefined PANCAN SU11274 sensitivity in vitro
EXP(CRM1) protein MCLP undefined PANCAN SU11274 resistance in vitro
Showing 1 to 7 of 7 rows

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