iGMDRD595

Canonical SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

InChI: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

InChI Key: GPXBXXGIAQBQNI-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NamePLX4032
CHEMBLCHEMBL1229517
Pubchem CID42611300
DRUGBANK IDDB08881
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

BRAF (P15056)

Drug-model tissue-cancer distribution: Bubble Plot

UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 2PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 10

Drug-gene pathway enrichments

6reactome: Gene expression (Transcription)6reactome: RNA Polymerase II Transcription6reactome: Generic Transcription Pathway3reactome: Signal Transduction3reactome: Transcriptional regulation by RUNX22reactome: Cell Cycle Checkpoints2biocarta: tumor suppressor arf inhibits ribosomal biogenesis2reactome: Death Receptor Signalling2reactome: G1/S DNA Damage Checkpoints2wikipathways: Adipogenesis

Drug-gene GO enrichments

5CC: nucleus5CC: cytosol5MF: protein binding4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding4BP: positive regulation of apoptotic process4CC: nucleoplasm3BP: positive regulation of transcription by RNA polymerase II2BP: negative regulation of transcription, DNA-templated2BP: osteoblast differentiation2MF: transcription coactivator activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
57580 PREX1 1
25937 WWTR1 1
472 ATM 1
10018 BCL2L11 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in PLX4032

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(S6_pS240S244) protein MCLP UTERUS undefined PLX.4032 resistance in vitro
EXP(PREX1) protein MCLP SKIN undefined PLX.4032 resistance in vitro
EXP(TWIST) protein MCLP SKIN undefined PLX.4032 resistance in vitro
EXP(RAPTOR) protein MCLP PANCREAS undefined PLX.4032 sensitivity in vitro
EXP(ATM) protein MCLP undefined PANCAN PLX.4032 resistance in vitro
EXP(BIM) protein MCLP undefined PANCAN PLX.4032 sensitivity in vitro
EXP(CLAUDIN7) protein MCLP undefined PANCAN PLX.4032 sensitivity in vitro
EXP(EGFR_pY1068) protein MCLP undefined PANCAN PLX.4032 sensitivity in vitro
EXP(HER2_pY1248) protein MCLP undefined PANCAN PLX.4032 sensitivity in vitro
EXP(SHC_pY317) protein MCLP undefined PANCAN PLX.4032 sensitivity in vitro
Showing 1 to 10 of 14 rows rows per page

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