CYP2S1
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cytochrome P450 family 2 subfamily S member 1 | MIM:611529 | Ensembl:ENSG00000167600 | HGNC:HGNC:15654 | PA27113 | 19q13.2 |
GO terms in CYP2S1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IBA | GO:0006082 | organic acid metabolic process |
| BP | IBA | GO:0006805 | xenobiotic metabolic process |
| BP | IBA | GO:0042738 | exogenous drug catabolic process |
| BP | IBA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| MF | IEA | GO:0005506 | iron ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008392 | arachidonic acid epoxygenase activity |
| MF | IBA | GO:0008395 | steroid hydroxylase activity |
| MF | TAS | GO:0008401 | retinoic acid 4-hydroxylase activity |
| MF | IBA | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| MF | IBA | GO:0020037 | heme binding |
| MF | IEA | GO:0020037 | heme binding |
| MF | IEA | GO:0070330 | aromatase activity |
Gene expression in normal tissue: CYP2S1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP2S1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| humancyc | PWY-5451 | acetone degradation I (to methylglyoxal) |
| humancyc | PWY-6398 | melatonin degradation I |
| humancyc | PWY-6402 | superpathway of melatonin degradation |
| humancyc | PWY66-201 | nicotine degradation IV |
| humancyc | PWY66-221 | nicotine degradation III |
| humancyc | PWY66-241 | bupropion degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP43 | Oxidation by Cytochrome P450 |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211958 | Miscellaneous substrates |
| reactome | R-HSA-211981 | Xenobiotics |
| reactome | R-HSA-211999 | CYP2E1 reactions |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP2S1
CLASSFICATION
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