CLDN1
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameclaudin 1 OMIM IDMIM:603718 Ensembl IDEnsembl:ENSG00000163347 HGNC IDHGNC:HGNC:2032 PHARMGKB IDPA26557 Map Location3q28 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in CLDN1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0008065 | establishment of blood-nerve barrier |
| BP | ISS | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0042538 | hyperosmotic salinity response |
| BP | IMP | GO:0045216 | cell-cell junction organization |
Gene expression in normal tissue: CLDN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLDN1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-420029 | Tight junction interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLDN1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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