GCNT3
Summary: This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glucosaminyl (N-acetyl) transferase 3, mucin type | MIM:606836 | Ensembl:ENSG00000140297 | HGNC:HGNC:4205 | PA28620 | 15q22.2 |
GO terms in GCNT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity |
| MF | IEA | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity |
| MF | IEA | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0002426 | immunoglobulin production in mucosal tissue |
| BP | NAS | GO:0005975 | carbohydrate metabolic process |
| BP | TAS | GO:0006493 | protein O-linked glycosylation |
| BP | TAS | GO:0016266 | O-glycan processing |
| BP | IEA | GO:0048729 | tissue morphogenesis |
| BP | IEA | GO:0050892 | intestinal absorption |
| BP | IEA | GO:0060993 | kidney morphogenesis |
Gene expression in normal tissue: GCNT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GCNT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00512 | Mucin type O-glycan biosynthesis - Homo sapiens (human) |
| humancyc | PWY-7433 | mucin core 1 and core 2 O-glycosylation |
| humancyc | PWY-7434 | terminal O-glycans residues modification |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-913709 | O-linked glycosylation of mucins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GCNT3
CLASSFICATION
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