GCNT3
Summary: This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606836 Ensembl IDEnsembl:ENSG00000140297 HGNC IDHGNC:HGNC:4205 PHARMGKB IDPA28620 Map Location15q22.2 | |||||
GO terms in GCNT3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity |
| MF | IEA | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity |
| MF | IEA | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: GCNT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GCNT3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00512 | Mucin type O-glycan biosynthesis - Homo sapiens (human) |
| humancyc | PWY-7433 | mucin core 1 and core 2 O-glycosylation |
| humancyc | PWY-7434 | terminal O-glycans residues modification |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD131 | Erlotinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GCNT3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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