Summary: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

V-set domain containing T cell activation inhibitor 1MIM:608162Ensembl:ENSG00000134258HGNC:HGNC:28873PA1426706111p13.1-p12

GO terms in VTCN1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005102signaling receptor binding
MFIEAGO:0005102signaling receptor binding
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
BPIEAGO:0001562response to protozoan
BPIBAGO:0001817regulation of cytokine production
BPIEAGO:0002250adaptive immune response
BPIEAGO:0042102positive regulation of T cell proliferation
BPIMPGO:0042130negative regulation of T cell proliferation
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0050776regulation of immune response
BPIBAGO:0050852T cell receptor signaling pathway
BPIMPGO:0050868negative regulation of T cell activation
BPIEAGO:0072602interleukin-4 secretion
BPIEAGO:0072643interferon-gamma secretion
BPIEAGO:1900042positive regulation of interleukin-2 secretion

Gene expression in normal tissue: VTCN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VTCN1

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VTCN1