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MAPK1

Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
mitogen-activated protein kinase 1	MIM:176948	Ensembl:ENSG00000100030	HGNC:HGNC:6871	PA30616	22q11.22

Gene Categories:

RNA DIRECTED DNA POLYMERASE SERINE THREONINE KINASE KINASE TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in MAPK1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0001784	phosphotyrosine residue binding
MF	IEA	GO:0003677	DNA binding
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IBA	GO:0004707	MAP kinase activity
MF	TAS	GO:0004707	MAP kinase activity
MF	IEA	GO:0004708	MAP kinase kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0008134	transcription factor binding
MF	ISS	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
MF	TAS	GO:0016301	kinase activity
MF	IPI	GO:0019902	phosphatase binding
MF	IEA	GO:0031435	mitogen-activated protein kinase kinase kinase binding
MF	IPI	GO:0042802	identical protein binding
CC	TAS	GO:0005576	extracellular region
CC	HDA	GO:0005634	nucleus
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	HDA	GO:0005737	cytoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	ISS	GO:0005737	cytoplasm
CC	TAS	GO:0005739	mitochondrion
CC	TAS	GO:0005769	early endosome
CC	TAS	GO:0005770	late endosome
CC	TAS	GO:0005794	Golgi apparatus
CC	IEA	GO:0005815	microtubule organizing center
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005856	cytoskeleton
CC	ISS	GO:0005886	plasma membrane
CC	ISS	GO:0005901	caveola
CC	TAS	GO:0005901	caveola
CC	TAS	GO:0005925	focal adhesion
CC	IEA	GO:0030424	axon
CC	IEA	GO:0031143	pseudopodium
CC	IEA	GO:0032839	dendrite cytoplasm
CC	IEA	GO:0032991	protein-containing complex
CC	TAS	GO:0035578	azurophil granule lumen
CC	IEA	GO:0043204	perikaryon
CC	ISS	GO:0072686	mitotic spindle
CC	TAS	GO:1904813	ficolin-1-rich granule lumen
BP	TAS	GO:0000165	MAPK cascade
BP	TAS	GO:0000187	activation of MAPK activity
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IEA	GO:0006915	apoptotic process
BP	TAS	GO:0006935	chemotaxis
BP	IEA	GO:0006974	cellular response to DNA damage stimulus
BP	IEA	GO:0007049	cell cycle
BP	TAS	GO:0007165	signal transduction
BP	IBA	GO:0007166	cell surface receptor signaling pathway
BP	TAS	GO:0007268	chemical synaptic transmission
BP	TAS	GO:0007411	axon guidance
BP	NAS	GO:0007611	learning or memory
BP	IEA	GO:0008284	positive regulation of cell proliferation
BP	TAS	GO:0008543	fibroblast growth factor receptor signaling pathway
BP	IBA	GO:0010468	regulation of gene expression
BP	IMP	GO:0010628	positive regulation of gene expression
BP	IDA	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
BP	TAS	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
BP	IEA	GO:0015966	diadenosine tetraphosphate biosynthetic process
BP	IEA	GO:0016032	viral process
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	ISS	GO:0018107	peptidyl-threonine phosphorylation
BP	IEA	GO:0019233	sensory perception of pain
BP	IEA	GO:0019858	cytosine metabolic process
BP	TAS	GO:0030168	platelet activation
BP	IEA	GO:0030278	regulation of ossification
BP	IEA	GO:0030335	positive regulation of cell migration
BP	IEA	GO:0030641	regulation of cellular pH
BP	IEA	GO:0030878	thyroid gland development
BP	ISS	GO:0031647	regulation of protein stability
BP	IEA	GO:0031663	lipopolysaccharide-mediated signaling pathway
BP	IMP	GO:0032212	positive regulation of telomere maintenance via telomerase
BP	TAS	GO:0032872	regulation of stress-activated MAPK cascade
BP	IEA	GO:0033160	positive regulation of protein import into nucleus, translocation
BP	IEA	GO:0033598	mammary gland epithelial cell proliferation
BP	IDA	GO:0034198	cellular response to amino acid starvation
BP	IMP	GO:0034614	cellular response to reactive oxygen species
BP	ISS	GO:0035094	response to nicotine
BP	IBA	GO:0035556	intracellular signal transduction
BP	TAS	GO:0038095	Fc-epsilon receptor signaling pathway
BP	TAS	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
BP	IDA	GO:0038127	ERBB signaling pathway
BP	IEA	GO:0042473	outer ear morphogenesis
BP	TAS	GO:0043312	neutrophil degranulation
BP	IEA	GO:0043330	response to exogenous dsRNA
BP	IEA	GO:0043627	response to estrogen
BP	IEA	GO:0045596	negative regulation of cell differentiation
BP	IEA	GO:0045727	positive regulation of translation
BP	IEA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEA	GO:0048538	thymus development
BP	IEA	GO:0050852	T cell receptor signaling pathway
BP	IEA	GO:0050853	B cell receptor signaling pathway
BP	TAS	GO:0051090	regulation of DNA-binding transcription factor activity
BP	IDA	GO:0051403	stress-activated MAPK cascade
BP	TAS	GO:0051493	regulation of cytoskeleton organization
BP	IMP	GO:0051973	positive regulation of telomerase activity
BP	IEA	GO:0060020	Bergmann glial cell differentiation
BP	IEA	GO:0060291	long-term synaptic potentiation
BP	IEA	GO:0060324	face development
BP	IEA	GO:0060425	lung morphogenesis
BP	IEA	GO:0060440	trachea formation
BP	IEA	GO:0060716	labyrinthine layer blood vessel development
BP	IEA	GO:0061308	cardiac neural crest cell development involved in heart development
BP	IDA	GO:0070371	ERK1 and ERK2 cascade
BP	TAS	GO:0070371	ERK1 and ERK2 cascade
BP	IDA	GO:0070849	response to epidermal growth factor
BP	IMP	GO:0071276	cellular response to cadmium ion
BP	IBA	GO:0071310	cellular response to organic substance
BP	IEA	GO:0071356	cellular response to tumor necrosis factor
BP	TAS	GO:0072584	caveolin-mediated endocytosis
BP	TAS	GO:0090170	regulation of Golgi inheritance
BP	IEA	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
BP	TAS	GO:1900034	regulation of cellular response to heat
BP	IMP	GO:1903351	cellular response to dopamine
BP	IMP	GO:1904355	positive regulation of telomere capping
BP	TAS	GO:2000641	regulation of early endosome to late endosome transport

Gene expression in normal tissue: MAPK1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK1

Database	Pathway ID	Pathway Des.
humancyc	PWY66-14	MAP kinase cascade
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04012	ErbB signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04072	Phospholipase D signaling pathway - Homo sapiens (human)
kegg	hsa04114	Oocyte meiosis - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04261	Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg	hsa04270	Vascular smooth muscle contraction - Homo sapiens (human)
kegg	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)
kegg	hsa04360	Axon guidance - Homo sapiens (human)
kegg	hsa04370	VEGF signaling pathway - Homo sapiens (human)
kegg	hsa04371	Apelin signaling pathway - Homo sapiens (human)
kegg	hsa04380	Osteoclast differentiation - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04520	Adherens junction - Homo sapiens (human)
kegg	hsa04540	Gap junction - Homo sapiens (human)
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04625	C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg	hsa04650	Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg	hsa04657	IL-17 signaling pathway - Homo sapiens (human)
kegg	hsa04658	Th1 and Th2 cell differentiation - Homo sapiens (human)
kegg	hsa04659	Th17 cell differentiation - Homo sapiens (human)
kegg	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegg	hsa04668	TNF signaling pathway - Homo sapiens (human)
kegg	hsa04713	Circadian entrainment - Homo sapiens (human)
kegg	hsa04720	Long-term potentiation - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04723	Retrograde endocannabinoid signaling - Homo sapiens (human)
kegg	hsa04724	Glutamatergic synapse - Homo sapiens (human)
kegg	hsa04725	Cholinergic synapse - Homo sapiens (human)
kegg	hsa04726	Serotonergic synapse - Homo sapiens (human)
kegg	hsa04730	Long-term depression - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04912	GnRH signaling pathway - Homo sapiens (human)
kegg	hsa04914	Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegg	hsa04915	Estrogen signaling pathway - Homo sapiens (human)
kegg	hsa04916	Melanogenesis - Homo sapiens (human)
kegg	hsa04917	Prolactin signaling pathway - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa04921	Oxytocin signaling pathway - Homo sapiens (human)
kegg	hsa04926	Relaxin signaling pathway - Homo sapiens (human)
kegg	hsa04930	Type II diabetes mellitus - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa04934	Cushing,s syndrome - Homo sapiens (human)
kegg	hsa04960	Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegg	hsa05010	Alzheimer,s disease - Homo sapiens (human)
kegg	hsa05020	Prion diseases - Homo sapiens (human)
kegg	hsa05034	Alcoholism - Homo sapiens (human)
kegg	hsa05131	Shigellosis - Homo sapiens (human)
kegg	hsa05132	Salmonella infection - Homo sapiens (human)
kegg	hsa05133	Pertussis - Homo sapiens (human)
kegg	hsa05140	Leishmaniasis - Homo sapiens (human)
kegg	hsa05142	Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegg	hsa05145	Toxoplasmosis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05160	Hepatitis C - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05164	Influenza A - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05214	Glioma - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05216	Thyroid cancer - Homo sapiens (human)
kegg	hsa05218	Melanoma - Homo sapiens (human)
kegg	hsa05219	Bladder cancer - Homo sapiens (human)
kegg	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)
kegg	hsa05221	Acute myeloid leukemia - Homo sapiens (human)
kegg	hsa05223	Non-small cell lung cancer - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05230	Central carbon metabolism in cancer - Homo sapiens (human)
kegg	hsa05231	Choline metabolism in cancer - Homo sapiens (human)
netpath	Pathway_Alpha6Beta4Integrin	Alpha6Beta4Integrin
netpath	Pathway_BCR	BCR
netpath	Pathway_BDNF	BDNF
netpath	Pathway_CRH	CRH
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_Fibroblast__growth__factor-1	Fibroblast growth factor-1
netpath	Pathway_Gastrin	Gastrin
netpath	Pathway_Ghrelin	Ghrelin
netpath	Pathway_ID	ID
netpath	Pathway_IL-7	IL-7
netpath	Pathway_IL1	IL1
netpath	Pathway_IL11	IL11
netpath	Pathway_IL2	IL2
netpath	Pathway_IL3	IL3
netpath	Pathway_IL4	IL4
netpath	Pathway_IL6	IL6
netpath	Pathway_IL9	IL9
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_Leptin	Leptin
netpath	Pathway_Notch	Notch
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_Prolactin	Prolactin
netpath	Pathway_RAGE	RAGE
netpath	Pathway_TCR	TCR
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
netpath	Pathway_TNFalpha	TNFalpha
netpath	Pathway_TSLP	TSLP
netpath	Pathway_TWEAK	TWEAK
biocarta	agrpathway	agrin in postsynaptic differentiation
biocarta	at1rpathway	angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocarta	barrestinsrcpathway	roles of arrestin dependent recruitment of src kinases in gpcr signaling
biocarta	barrmapkpathway	role of -arrestins in the activation and targeting of map kinases
biocarta	biopeptidespathway	bioactive peptide induced signaling pathway
biocarta	cardiacegfpathway	role of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocarta	ccr3pathway	ccr3 signaling in eosinophils
biocarta	cdk5pathway	phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocarta	cdmacpathway	cadmium induces dna synthesis and proliferation in macrophages
biocarta	ceramidepathway	ceramide signaling pathway
biocarta	crebpathway	transcription factor creb and its extracellular signals
biocarta	ecmpathway	erk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocarta	edg1pathway	phospholipids as signalling intermediaries
biocarta	eif4pathway	regulation of eif-4e and p70s6 kinase
biocarta	erk5pathway	role of erk5 in neuronal survival pathway
biocarta	erkpathway	erk1/erk2 mapk signaling pathway
biocarta	fcer1pathway	fc epsilon receptor i signaling in mast cells
biocarta	fmlppathway	fmlp induced chemokine gene expression in hmc-1 cells
biocarta	hcmvpathway	human cytomegalovirus and map kinase pathways
biocarta	her2pathway	role of erbb2 in signal transduction and oncology
biocarta	il2rbpathway	il-2 receptor beta chain in t cell activation
biocarta	keratinocytepathway	keratinocyte differentiation
biocarta	malpathway	role of mal in rho-mediated activation of srf
biocarta	mapkpathway	mapkinase signaling pathway
biocarta	mcalpainpathway	mcalpain and friends in cell motility
biocarta	melanocytepathway	melanocyte development and pigmentation pathway
biocarta	mprpathway	how progesterone initiates the oocyte maturation
biocarta	pparapathway	mechanism of gene regulation by peroxisome proliferators via ppara
biocarta	pyk2pathway	links between pyk2 and map kinases
biocarta	raccycdpathway	influence of ras and rho proteins on g1 to s transition
biocarta	sam68pathway	regulation of splicing through sam68
biocarta	sppapathway	aspirin blocks signaling pathway involved in platelet activation
biocarta	sprypathway	sprouty regulation of tyrosine kinase signals
biocarta	stat3pathway	stat3 signaling pathway
biocarta	tffpathway	trefoil factors initiate mucosal healing
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-111885	Opioid Signalling
reactome	R-HSA-111995	phospho-PLA2 pathway
reactome	R-HSA-111996	Ca-dependent events
reactome	R-HSA-112040	G-protein mediated events
reactome	R-HSA-112043	PLC beta mediated events
reactome	R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission
reactome	R-HSA-112315	Transmission across Chemical Synapses
reactome	R-HSA-112316	Neuronal System
reactome	R-HSA-112409	RAF-independent MAPK1/3 activation
reactome	R-HSA-112411	MAPK1 (ERK2) activation
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1295596	Spry regulation of FGF signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1643685	Disease
reactome	R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade
reactome	R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade
reactome	R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane
reactome	R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane
reactome	R-HSA-166166	MyD88-independent TLR4 cascade
reactome	R-HSA-166166	MyD88-independent TLR4 cascade
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade
reactome	R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade
reactome	R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade
reactome	R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade
reactome	R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade
reactome	R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade
reactome	R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade
reactome	R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade
reactome	R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade
reactome	R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade
reactome	R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade
reactome	R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade
reactome	R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade
reactome	R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168898	Toll-Like Receptors Cascades
reactome	R-HSA-168898	Toll-Like Receptors Cascades
reactome	R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade
reactome	R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade
reactome	R-HSA-187037	Signaling by NTRK1 (TRKA)
reactome	R-HSA-187037	Signaling by NTRK1 (TRKA)
reactome	R-HSA-190236	Signaling by FGFR
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-198725	Nuclear Events (kinase and transcription factor activation)
reactome	R-HSA-198725	Nuclear Events (kinase and transcription factor activation)
reactome	R-HSA-198753	ERK/MAPK targets
reactome	R-HSA-198753	ERK/MAPK targets
reactome	R-HSA-199418	Negative regulation of the PI3K/AKT network
reactome	R-HSA-202670	ERKs are inactivated
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2559580	Oxidative Stress Induced Senescence
reactome	R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-2559585	Oncogene Induced Senescence
reactome	R-HSA-2559585	Oncogene Induced Senescence
reactome	R-HSA-2871796	FCERI mediated MAPK activation
reactome	R-HSA-3371453	Regulation of HSF1-mediated heat shock response
reactome	R-HSA-3371556	Cellular response to heat stress
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-373760	L1CAM interactions
reactome	R-HSA-375165	NCAM signaling for neurite out-growth
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-416476	G alpha (q) signalling events
reactome	R-HSA-418594	G alpha (i) signalling events
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-437239	Recycling pathway of L1
reactome	R-HSA-438064	Post NMDA receptor activation events
reactome	R-HSA-442742	CREB phosphorylation through the activation of Ras
reactome	R-HSA-442755	Activation of NMDA receptor and postsynaptic events
reactome	R-HSA-444257	RSK activation
reactome	R-HSA-445144	Signal transduction by L1
reactome	R-HSA-448424	Interleukin-17 signaling
reactome	R-HSA-448424	Interleukin-17 signaling
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases
reactome	R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases
reactome	R-HSA-450294	MAP kinase activation
reactome	R-HSA-450294	MAP kinase activation
reactome	R-HSA-450341	Activation of the AP-1 family of transcription factors
reactome	R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)
reactome	R-HSA-5654726	Negative regulation of FGFR1 signaling
reactome	R-HSA-5654727	Negative regulation of FGFR2 signaling
reactome	R-HSA-5654732	Negative regulation of FGFR3 signaling
reactome	R-HSA-5654733	Negative regulation of FGFR4 signaling
reactome	R-HSA-5654736	Signaling by FGFR1
reactome	R-HSA-5654738	Signaling by FGFR2
reactome	R-HSA-5654741	Signaling by FGFR3
reactome	R-HSA-5654743	Signaling by FGFR4
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs
reactome	R-HSA-5673001	RAF/MAP kinase cascade
reactome	R-HSA-5674135	MAP2K and MAPK activation
reactome	R-HSA-5674499	Negative feedback regulation of MAPK pathway
reactome	R-HSA-5675221	Negative regulation of MAPK pathway
reactome	R-HSA-5683057	MAPK family signaling cascades
reactome	R-HSA-5684996	MAPK1/MAPK3 signaling
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants
reactome	R-HSA-6802948	Signaling by high-kinase activity BRAF mutants
reactome	R-HSA-6802949	Signaling by RAS mutants
reactome	R-HSA-6802952	Signaling by BRAF and RAF fusions
reactome	R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF
reactome	R-HSA-6802957	Oncogenic MAPK signaling
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactome	R-HSA-68875	Mitotic Prophase
reactome	R-HSA-68886	M Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-74749	Signal attenuation
reactome	R-HSA-74751	Insulin receptor signalling cascade
reactome	R-HSA-74752	Signaling by Insulin receptor
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-879415	Advanced glycosylation endproduct receptor signaling
reactome	R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK
reactome	R-HSA-8878166	Transcriptional regulation by RUNX2
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-8940973	RUNX2 regulates osteoblast differentiation
reactome	R-HSA-8941326	RUNX2 regulates bone development
reactome	R-HSA-8943724	Regulation of PTEN gene transcription
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling
reactome	R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling
reactome	R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactome	R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactome	R-HSA-975155	MyD88 dependent cascade initiated on endosome
reactome	R-HSA-975155	MyD88 dependent cascade initiated on endosome
reactome	R-HSA-975871	MyD88 cascade initiated on plasma membrane
reactome	R-HSA-975871	MyD88 cascade initiated on plasma membrane
reactome	R-HSA-982772	Growth hormone receptor signaling
smpdb	SMP00320	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb	SMP00321	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb	SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells
smpdb	SMP00391	Insulin Signalling
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP1434	Osteopontin Signaling
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1528	Physiological and Pathological Hypertrophy of the Heart
wikipathways	WP1539	Angiogenesis
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1584	Type II diabetes mellitus
wikipathways	WP1591	Heart Development
wikipathways	WP185	Integrin-mediated Cell Adhesion
wikipathways	WP195	IL-1 signaling pathway
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP1993	Angiogenesis overview
wikipathways	WP2018	RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathways	WP2032	Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP2035	Follicle Stimulating Hormone (FSH) signaling pathway
wikipathways	WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways	WP2037	Prolactin Signaling Pathway
wikipathways	WP205	IL-7 Signaling Pathway
wikipathways	WP2059	Alzheimers Disease
wikipathways	WP2112	IL17 signaling pathway
wikipathways	WP2197	Endothelin Pathways
wikipathways	WP22	IL-9 Signaling Pathway
wikipathways	WP2203	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP2263	Androgen Receptor Network in Prostate Cancer
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2324	AGE-RAGE pathway
wikipathways	WP2332	Interleukin-11 Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP2374	Oncostatin M Signaling Pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2431	Spinal Cord Injury
wikipathways	WP244	Alpha 6 Beta 4 signaling pathway
wikipathways	WP2526	PDGF Pathway
wikipathways	WP2586	Aryl Hydrocarbon Receptor
wikipathways	WP259	Nifedipine Activity
wikipathways	WP2593	JAK-STAT
wikipathways	WP26	Signal Transduction of S1P Receptor
wikipathways	WP262	EBV LMP1 signaling
wikipathways	WP2636	Common Pathways Underlying Drug Addiction
wikipathways	WP2637	Structural Pathway of Interleukin 1 (IL-1)
wikipathways	WP2795	Cardiac Hypertrophic Response
wikipathways	WP2828	Bladder Cancer
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways	WP2868	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP306	Focal Adhesion
wikipathways	WP313	Signaling of Hepatocyte Growth Factor Receptor
wikipathways	WP3301	MFAP5-mediated ovarian cancer cell motility and invasiveness
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway
wikipathways	WP363	Wnt Signaling Pathway
wikipathways	WP364	IL-6 signaling pathway
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3668	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathways	WP3676	BDNF-TrkB Signaling
wikipathways	WP3680	Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3849	MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ
wikipathways	WP3853	ERK Pathway in Huntington,s Disease
wikipathways	WP3858	Toll-like Receptor Signaling
wikipathways	WP3859	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
wikipathways	WP3879	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP3931	ESC Pluripotency Pathways
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP395	IL-4 Signaling Pathway
wikipathways	WP3980	Protein alkylation leading to liver fibrosis
wikipathways	WP3981	miRNA regulation of prostate cancer signaling pathways
wikipathways	WP3995	Prion disease pathway
wikipathways	WP4155	Endometrial cancer
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4205	MET in type 1 papillary renal cell carcinoma
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP422	MAPK Cascade
wikipathways	WP4223	Ras Signaling
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP437	EGF-EGFR Signaling Pathway
wikipathways	WP481	Insulin Signaling
wikipathways	WP49	IL-2 Signaling Pathway
wikipathways	WP51	Regulation of Actin Cytoskeleton
wikipathways	WP581	EPO Receptor Signaling
wikipathways	WP615	Senescence and Autophagy in Cancer
wikipathways	WP673	ErbB Signaling Pathway
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathways	WP710	DNA Damage Response (only ATM dependent)
wikipathways	WP712	Estrogen signaling pathway
wikipathways	WP716	Vitamin A and Carotenoid Metabolism
wikipathways	WP722	Serotonin HTR1 Group and FOS Pathway
wikipathways	WP732	Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
wikipathways	WP734	Serotonin Receptor 4-6-7 and NR3C Signaling
wikipathways	WP75	Toll-like Receptor Signaling Pathway
pid	alk1pathway	ALK1 signaling events
pid	angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
pid	anthraxpathway	Cellular roles of Anthrax toxin
pid	ar_nongenomic_pathway	Nongenotropic Androgen signaling
pid	arf6downstreampathway	Arf6 downstream pathway
pid	atf2_pathway	ATF-2 transcription factor network
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	avb3_opn_pathway	Osteopontin-mediated events
pid	bcr_5pathway	BCR signaling pathway
pid	bmppathway	BMP receptor signaling
pid	cd8tcrdownstreampathway	Downstream signaling in naïve CD8+ T cells
pid	cdc42_pathway	CDC42 signaling events
pid	ceramide_pathway	Ceramide signaling pathway
pid	cxcr3pathway	CXCR3-mediated signaling events
pid	endothelinpathway	Endothelins
pid	ephbfwdpathway	EPHB forward signaling
pid	erbb1_downstream_pathway	ErbB1 downstream signaling
pid	erbb2erbb3pathway	ErbB2/ErbB3 signaling events
pid	erbb4_pathway	ErbB4 signaling events
pid	fak_pathway	Signaling events mediated by focal adhesion kinase
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	fgf_pathway	FGF signaling pathway
pid	gmcsf_pathway	GMCSF-mediated signaling events
pid	ifngpathway	IFN-gamma pathway
pid	il2_1pathway	IL2-mediated signaling events
pid	lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
pid	mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	mtor_4pathway	mTOR signaling pathway
pid	netrin_pathway	Netrin-mediated signaling events
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	pi3kcibpathway	Class IB PI3K non-lipid kinase events
pid	prlsignalingeventspathway	Signaling events mediated by PRL
pid	ps1pathway	Presenilin action in Notch and Wnt signaling
pid	reg_gr_pathway	Glucocorticoid receptor regulatory network
pid	ret_pathway	Signaling events regulated by Ret tyrosine kinase
pid	retinoic_acid_pathway	Retinoic acid receptors-mediated signaling
pid	s1p_s1p1_pathway	S1P1 pathway
pid	s1p_s1p2_pathway	S1P2 pathway
pid	s1p_s1p3_pathway	S1P3 pathway
pid	s1p_s1p4_pathway	S1P4 pathway
pid	smad2_3pathway	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
pid	syndecan_1_pathway	Syndecan-1-mediated signaling events
pid	syndecan_2_pathway	Syndecan-2-mediated signaling events
pid	tcrraspathway	Ras signaling in the CD4+ TCR pathway
pid	telomerasepathway	Regulation of Telomerase
pid	trail_pathway	TRAIL signaling pathway
pid	trkrpathway	Neurotrophic factor-mediated Trk receptor signaling
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
pid	vegfr1_pathway	VEGFR1 specific signals
pharmgkb	PA162356267	EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkb	PA165110622	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
pharmgkb	PA165959425	Pathway_PA165959425
pharmgkb	PA165959584	Sorafenib Pharmacodynamics
pharmgkb	PA165980050	Vemurafenib Pathway, Pharmacodynamics
pharmgkb	PA165980050	update your name in edit mode
pharmgkb	PA165984799	Diuretics Pathway, Pharmacodynamics
pharmgkb	PA2023	ACE Inhibitor Pathway, Pharmacodynamics
pharmgkb	PA2024	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkb	PA2032	VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD280	CYTOCHALASIN B	3
iGMDRD131	Erlotinib	1
iGMDRD635	WZ 4002	1
iGMDRD152	179324-69-7	3
iGMDRD61	Kinetin riboside	3
iGMDRD512	nutlin 3	6
iGMDRD185	DMOG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.