iGMDRD635

Canonical SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

InChI: InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)

InChI Key: ITTRLTNMFYIYPA-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameWZ 4002
CHEMBLCHEMBL1229592
Pubchem CID44607500
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

EGFR

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1

Drug-gene pathway enrichments

2reactome: Toll Like Receptor 7/8 (TLR7/8) Cascade2reactome: Toll Like Receptor TLR6:TLR2 Cascade2reactome: Toll Like Receptor TLR1:TLR2 Cascade2reactome: Toll Like Receptor 5 (TLR5) Cascade2reactome: Toll Like Receptor 3 (TLR3) Cascade2reactome: Innate Immune System2reactome: Immune System2reactome: Nuclear Events (kinase and transcription factor activation)2reactome: ERK/MAPK targets2reactome: Signaling by NTRK1 (TRKA)

Drug-gene GO enrichments

4CC: nucleus4CC: cytoplasm2BP: protein phosphorylation2CC: caveola2BP: ERK1 and ERK2 cascade2MF: protein serine/threonine kinase activity2MF: MAP kinase activity1BP: outer ear morphogenesis1BP: ERBB signaling pathway1BP: Fc-gamma receptor signaling pathway involved in phagocytosis

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5594 MAPK1 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in WZ 4002

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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