KLK8
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605644 Ensembl IDEnsembl:ENSG00000129455 HGNC IDHGNC:HGNC:6369 PHARMGKB IDPA30158 Map Location19q13.41 | |||||
GO terms in KLK8
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0030141 | secretory granule |
| CC | IDA | GO:0097180 | serine protease inhibitor complex |
| BP | IEA | GO:0006508 | proteolysis |
Gene expression in normal tissue: KLK8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLK8
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD131 | Erlotinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLK8
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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