KLK8
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kallikrein related peptidase 8 | MIM:605644 | Ensembl:ENSG00000129455 | HGNC:HGNC:6369 | PA30158 | 19q13.41 |
GO terms in KLK8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0030141 | secretory granule |
| CC | IDA | GO:0097180 | serine protease inhibitor complex |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IBA | GO:0007613 | memory |
| BP | ISS | GO:0007613 | memory |
| BP | ISS | GO:0008219 | cell death |
| BP | ISS | GO:0009611 | response to wounding |
| BP | ISS | GO:0031642 | negative regulation of myelination |
| BP | ISS | GO:0043616 | keratinocyte proliferation |
| BP | ISS | GO:0048681 | negative regulation of axon regeneration |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | ISS | GO:0048812 | neuron projection morphogenesis |
| BP | ISS | GO:0050807 | regulation of synapse organization |
| BP | IEA | GO:0050808 | synapse organization |
| MF | IDA | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: KLK8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLK8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLK8
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