KLK8


Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kallikrein related peptidase 8MIM:605644Ensembl:ENSG00000129455HGNC:HGNC:6369PA3015819q13.41

Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in KLK8


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCISSGO:0005615extracellular space
CCIDAGO:0005737cytoplasm
CCIBAGO:0030141secretory granule
CCIDAGO:0097180serine protease inhibitor complex
BPIEAGO:0006508proteolysis
BPIBAGO:0007613memory
BPISSGO:0007613memory
BPISSGO:0008219cell death
BPISSGO:0009611response to wounding
BPISSGO:0031642negative regulation of myelination
BPISSGO:0043616keratinocyte proliferation
BPISSGO:0048681negative regulation of axon regeneration
BPIBAGO:0048812neuron projection morphogenesis
BPISSGO:0048812neuron projection morphogenesis
BPISSGO:0050807regulation of synapse organization
BPIEAGO:0050808synapse organization
MFIDAGO:0004252serine-type endopeptidase activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: KLK8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KLK8


DatabasePathway IDPathway Des.
wikipathwaysWP2431Spinal Cord Injury
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLK8

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