KLC3

Summary: This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namekinesin light chain 3
OMIM IDMIM:601334
Ensembl IDEnsembl:ENSG00000104892
HGNC IDHGNC:HGNC:20717
PHARMGKB IDPA142671588
Map Location19q13.32

GO terms in KLC3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0008088 axo-dendritic transport
CC IEA GO:0005737 cytoplasm
CC IEA GO:0005871 kinesin complex
CC IEA GO:0005874 microtubule
CC IEA GO:0031514 motile cilium
CC IEA GO:0035253 ciliary rootlet
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Gene expression in normal tissue: KLC3

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

EGFR signaling1ERK MAPK signaling1

Pathways in KLC3


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Database
Pathway ID
Pathway Des.
kegg hsa05132 Salmonella infection - Homo sapiens (human)
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-168256 Immune System
reactome R-HSA-194315 Signaling by Rho GTPases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD131 Erlotinib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KLC3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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