Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008].

gamma-aminobutyric acid type A receptor epsilon subunitMIM:300093Ensembl:ENSG00000102287HGNC:HGNC:4085PA28499Xq28

GO terms in GABRE

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIBAGO:0032590dendrite membrane
CCIEAGO:0034707chloride channel complex
CCIBAGO:0043005neuron projection
CCIEAGO:0045211postsynaptic membrane
CCIBAGO:1902711GABA-A receptor complex
CCIDAGO:1902711GABA-A receptor complex
BPIBAGO:0007165signal transduction
BPIEAGO:0007165signal transduction
BPIBAGO:0007214gamma-aminobutyric acid signaling pathway
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0034220ion transmembrane transport
BPIBAGO:0042391regulation of membrane potential
BPIBAGO:0050877nervous system process
BPIBAGO:0051932synaptic transmission, GABAergic
BPIBAGO:0060078regulation of postsynaptic membrane potential
BPIBAGO:1902476chloride transmembrane transport
BPIEAGO:1902476chloride transmembrane transport
BPIDAGO:2001226negative regulation of chloride transport
MFIBAGO:0004890GABA-A receptor activity
MFIEAGO:0004890GABA-A receptor activity
MFIBAGO:0005230extracellular ligand-gated ion channel activity
MFIBAGO:0005237inhibitory extracellular ligand-gated ion channel activity
MFIBAGO:0005254chloride channel activity
MFIBAGO:0008503benzodiazepine receptor activity
MFIBAGO:0022851GABA-gated chloride ion channel activity
MFIDAGO:0022851GABA-gated chloride ion channel activity
MFIBAGO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gene expression in normal tissue: GABRE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GABRE

DatabasePathway IDPathway Des.
wikipathwaysWP4159GABA receptor Signaling
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GABRE