ARFGAP1
Summary: The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADP ribosylation factor GTPase activating protein 1 | MIM:608377 | Ensembl:ENSG00000101199 | HGNC:HGNC:15852 | PA164741246 | 20q13.33 |
GO terms in ARFGAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0014069 | postsynaptic density |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0030100 | regulation of endocytosis |
| BP | IEA | GO:0030100 | regulation of endocytosis |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
Gene expression in normal tissue: ARFGAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARFGAP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | arappathway | adp-ribosylation factor |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| pid | arf_3pathway | Arf1 pathway |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD218 | XAV 939 | 1 |
| iGMDRD776 | QL-XI-92 | 1 |
| iGMDRD281 | Vinorelbine base | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD12 | Bicalutamide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARFGAP1
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