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KCNK1

Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namepotassium two pore domain channel subfamily K member 1 OMIM IDMIM:601745 Ensembl IDEnsembl:ENSG00000135750 HGNC IDHGNC:HGNC:6272 PHARMGKB IDPA219 Map Location1q42.2

Gene Categories:

ION CHANNEL TRANSPORTER DRUGGABLE GENOME

GO terms in KCNK1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0005887	integral component of plasma membrane
CC	ISS	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0008076	voltage-gated potassium channel complex
CC	IDA	GO:0016021	integral component of membrane

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Gene expression in normal tissue: KCNK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNK1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-112316	Neuronal System
reactome	R-HSA-1296071	Potassium Channels
reactome	R-HSA-1296346	Tandem pore domain potassium channels
reactome	R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
reactome	R-HSA-397014	Muscle contraction
reactome	R-HSA-5576886	Phase 4 - resting membrane potential

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD131	Erlotinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNK1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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