KCNK1
Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium two pore domain channel subfamily K member 1 | MIM:601745 | Ensembl:ENSG00000135750 | HGNC:HGNC:6272 | PA219 | 1q42.2 |
GO terms in KCNK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0031526 | brush border membrane |
| CC | IDA | GO:0034705 | potassium channel complex |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0045202 | synapse |
| CC | IEA | GO:0055037 | recycling endosome |
| CC | IEA | GO:1902937 | inward rectifier potassium channel complex |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IBA | GO:0030322 | stabilization of membrane potential |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | IDA | GO:0035725 | sodium ion transmembrane transport |
| BP | IMP | GO:0060075 | regulation of resting membrane potential |
| BP | TAS | GO:0061337 | cardiac conduction |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| MF | TAS | GO:0005242 | inward rectifier potassium channel activity |
| MF | IDA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IDA | GO:0005267 | potassium channel activity |
| MF | TAS | GO:0005267 | potassium channel activity |
| MF | IDA | GO:0005272 | sodium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0022841 | potassium ion leak channel activity |
| MF | IDA | GO:0022841 | potassium ion leak channel activity |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: KCNK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296346 | Tandem pore domain potassium channels |
| reactome | R-HSA-1299308 | Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576886 | Phase 4 - resting membrane potential |
| reactome | R-HSA-5576891 | Cardiac conduction |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNK1
CLASSFICATION
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