PAPPA2
Summary: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pappalysin 2 | Ensembl:ENSG00000116183 | HGNC:HGNC:14615 | PA33373 | 1q25.2 |
GO terms in PAPPA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | NAS | GO:0008270 | zinc ion binding |
| BP | NAS | GO:0001558 | regulation of cell growth |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0009651 | response to salt stress |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0060349 | bone morphogenesis |
| CC | TAS | GO:0005576 | extracellular region |
| CC | NAS | GO:0005622 | intracellular |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PAPPA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PAPPA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PAPPA2
CLASSFICATION
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