PAPPA2

Summary: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepappalysin 2
OMIM ID
Ensembl IDEnsembl:ENSG00000116183
HGNC IDHGNC:HGNC:14615
PHARMGKB IDPA33373
Map Location1q25.2

GO terms in PAPPA2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004222 metalloendopeptidase activity
MF TAS GO:0004222 metalloendopeptidase activity
MF IDA GO:0008237 metallopeptidase activity
MF NAS GO:0008270 zinc ion binding
BP NAS GO:0001558 regulation of cell growth
BP IDA GO:0006508 proteolysis
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Gene expression in normal tissue: PAPPA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PAPPA2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD131 Erlotinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAPPA2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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