UPK2
Summary: This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| uroplakin 2 | MIM:611558 | Ensembl:ENSG00000110375 | HGNC:HGNC:12579 | PA37211 | 11q23.3 |
GO terms in UPK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0030855 | epithelial cell differentiation |
| BP | IDA | GO:0030855 | epithelial cell differentiation |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0016324 | apical plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: UPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UPK2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UPK2
CLASSFICATION
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