UPK2

Summary: This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameuroplakin 2
OMIM IDMIM:611558
Ensembl IDEnsembl:ENSG00000110375
HGNC IDHGNC:HGNC:12579
PHARMGKB IDPA37211
Map Location11q23.3

GO terms in UPK2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
BP TAS GO:0007275 multicellular organism development
BP IBA GO:0030855 epithelial cell differentiation
BP IDA GO:0030855 epithelial cell differentiation
CC TAS GO:0005887 integral component of plasma membrane
CC IBA GO:0016324 apical plasma membrane
Showing 1 to 6 of 7 rows

Gene expression in normal tissue: UPK2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

EGFR signaling1

Pathways in UPK2


Loading, please wait...
Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD131 Erlotinib 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UPK2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.