EPB41L1


Summary: Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
erythrocyte membrane protein band 4.1 like 1MIM:602879Ensembl:ENSG00000088367HGNC:HGNC:3378PA2781120q11.23

GO terms in EPB41L1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003779actin binding
MFIPIGO:0005515protein binding
BPIEAGO:0030866cortical actin cytoskeleton organization
BPIBAGO:0031032actomyosin structure organization
CCTASGO:0005829cytosol
CCIBAGO:0005856cytoskeleton
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: EPB41L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPB41L1


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPB41L1

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