Summary: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012].

calcium voltage-gated channel subunit alpha1 CMIM:114205Ensembl:ENSG00000151067HGNC:HGNC:1390PA8312p13.33

GO terms in CACNA1C

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005891voltage-gated calcium channel complex
CCIDAGO:0014069postsynaptic density
CCIDAGO:0016021integral component of membrane
CCISSGO:0030018Z disc
CCIDAGO:1990454L-type voltage-gated calcium channel complex
BPIMPGO:0002520immune system development
BPIBAGO:0006816calcium ion transport
BPIDAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIMPGO:0007507heart development
BPTASGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
BPIMPGO:0035115embryonic forelimb morphogenesis
BPTASGO:0035585calcium-mediated signaling using extracellular calcium source
BPIMPGO:0043010camera-type eye development
BPTASGO:0050796regulation of insulin secretion
BPTASGO:0060402calcium ion transport into cytosol
BPIMPGO:0061337cardiac conduction
BPIDAGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channel
BPIBAGO:0070509calcium ion import
BPIDAGO:0070588calcium ion transmembrane transport
BPIMPGO:0070588calcium ion transmembrane transport
BPIMPGO:0086002cardiac muscle cell action potential involved in contraction
BPIMPGO:0086012membrane depolarization during cardiac muscle cell action potential
BPIMPGO:0086045membrane depolarization during AV node cell action potential
BPTASGO:0086064cell communication by electrical coupling involved in cardiac conduction
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIMPGO:0098911regulation of ventricular cardiac muscle cell action potential
BPIMPGO:0098912membrane depolarization during atrial cardiac muscle cell action potential
MFIBAGO:0005245voltage-gated calcium channel activity
MFIDAGO:0005245voltage-gated calcium channel activity
MFIMPGO:0005245voltage-gated calcium channel activity
MFTASGO:0005245voltage-gated calcium channel activity
MFIPIGO:0005515protein binding
MFIPIGO:0005516calmodulin binding
MFIBAGO:0008331high voltage-gated calcium channel activity
MFIDAGO:0008331high voltage-gated calcium channel activity
MFTASGO:0008331high voltage-gated calcium channel activity
MFIEAGO:0046872metal ion binding
MFIPIGO:0051393alpha-actinin binding
MFIMPGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potential
MFIMPGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potential
MFIMPGO:0086056voltage-gated calcium channel activity involved in AV node cell action potential

Gene expression in normal tissue: CACNA1C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNA1C

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
reactomeR-HSA-5576893Phase 2 - plateau phase
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00619Felodipine Metabolism Pathway
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
wikipathwaysWP1603Nicotine Activity on Chromaffin Cells
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04742Taste transduction - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA162355620Nicotine Pathway (Chromaffin Cell), Pharmacodynamics
pharmgkbPA165959313Valproic Acid Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2030Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
pharmgkbPA2042Sympathetic Nerve Pathway (Neuroeffector Junction)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNA1C