FOLR3
Summary: This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| folate receptor 3 | MIM:602469 | Ensembl:ENSG00000110203 | HGNC:HGNC:3795 | PA28211 | 11q13.4 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FOLR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007342 | fusion of sperm to egg plasma membrane involved in single fertilization |
| BP | TAS | GO:0015884 | folic acid transport |
| BP | IBA | GO:0035036 | sperm-egg recognition |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0016020 | membrane |
| CC | TAS | GO:0019898 | extrinsic component of membrane |
| CC | IBA | GO:0031362 | anchored component of external side of plasma membrane |
| CC | TAS | GO:0035580 | specific granule lumen |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| MF | IEA | GO:0005542 | folic acid binding |
Gene expression in normal tissue: FOLR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOLR3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| wikipathways | WP176 | Folate Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOLR3
CLASSFICATION
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