FOLR3
Summary: This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602469 Ensembl IDEnsembl:ENSG00000110203 HGNC IDHGNC:HGNC:3795 PHARMGKB IDPA28211 Map Location11q13.4 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in FOLR3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007342 | fusion of sperm to egg plasma membrane involved in single fertilization |
| BP | TAS | GO:0015884 | folic acid transport |
| BP | IBA | GO:0035036 | sperm-egg recognition |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | TAS | GO:0005576 | extracellular region |
Gene expression in normal tissue: FOLR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOLR3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| wikipathways | WP176 | Folate Metabolism |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOLR3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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