TNK1


Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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GO terms in TNK1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006468 protein phosphorylation
BP IBA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
BP IBA GO:0030154 cell differentiation
BP IEA GO:0030308 negative regulation of cell growth
BP IBA GO:0038083 peptidyl-tyrosine autophosphorylation
BP IBA GO:0042127 regulation of cell proliferation
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Gene expression in normal tissue: TNK1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 39BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 12LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9

Gene-drug pathway distribution

undefined15Apoptosis regulation1Chromatin histone acetylation1DNA replication1EGFR signaling1Other, kinases1ERK MAPK signaling1

Pathways in TNK1


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Database
Pathway ID
Pathway Des.
wikipathways WP306 Focal Adhesion
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD945 ML214 4
iGMDRD394 BX-795 3
iGMDRD280 CYTOCHALASIN B 3
iGMDRD679 Bistramide A 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNK1

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Level
Reference ID
Tissue
Cancer
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