TNK1
Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tyrosine kinase non receptor 1 | MIM:608076 | Ensembl:ENSG00000174292 | HGNC:HGNC:11940 | PA36630 | 17p13.1 |
GO terms in TNK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030308 | negative regulation of cell growth |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0046580 | negative regulation of Ras protein signal transduction |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0016020 | membrane |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | NAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: TNK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 4 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNK1
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