Summary: The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

solute carrier family 6 member 11MIM:607952Ensembl:ENSG00000132164HGNC:HGNC:11044PA359073p25.3

GO terms in SLC6A11

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007420brain development
BPIEAGO:0015812gamma-aminobutyric acid transport
BPIBAGO:0035725sodium ion transmembrane transport
BPIEAGO:0042493response to drug
BPIEAGO:0055085transmembrane transport
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0016021integral component of membrane
CCIEAGO:0042995cell projection
CCIBAGO:0043005neuron projection
MFIBAGO:0005215transporter activity
MFIBAGO:0005332gamma-aminobutyric acid:sodium symporter activity
MFTASGO:0005332gamma-aminobutyric acid:sodium symporter activity
MFIBAGO:0042165neurotransmitter binding
MFIEAGO:0042165neurotransmitter binding

Gene expression in normal tissue: SLC6A11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC6A11

DatabasePathway IDPathway Des.
reactomeR-HSA-112310Neurotransmitter release cycle
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-351202Metabolism of polyamines
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425366Transport of bile salts and organic acids, metal ions and amine compounds
reactomeR-HSA-425407SLC-mediated transmembrane transport
reactomeR-HSA-442660Na+/Cl- dependent neurotransmitter transporters
reactomeR-HSA-71288Creatine metabolism
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-888590GABA synthesis, release, reuptake and degradation
reactomeR-HSA-888593Reuptake of GABA
pharmgkbPA165111376Benzodiazepine Pathway, Pharmacodynamics
kegghsa04727GABAergic synapse - Homo sapiens (human)
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP4159GABA receptor Signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC6A11