PDK3


Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pyruvate dehydrogenase kinase 3MIM:300906Ensembl:ENSG00000067992HGNC:HGNC:8811PA33156Xp22.11

GO terms in PDK3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006006glucose metabolic process
BPIMPGO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate
BPTASGO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate
BPIMPGO:0010906regulation of glucose metabolic process
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0035357peroxisome proliferator activated receptor signaling pathway
BPISSGO:0071333cellular response to glucose stimulus
BPIMPGO:0071398cellular response to fatty acid
BPIMPGO:0097411hypoxia-inducible factor-1alpha signaling pathway
BPIMPGO:2000377regulation of reactive oxygen species metabolic process
CCIDAGO:0005730nucleolus
CCIDAGO:0005739mitochondrion
CCTASGO:0005759mitochondrial matrix
MFIDAGO:0004672protein kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFEXPGO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity
MFIDAGO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding

Gene expression in normal tissue: PDK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDK3


DatabasePathway IDPathway Des.
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complex
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-70268Pyruvate metabolism
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle
reactomeR-HSA-9006931Signaling by Nuclear Receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD483SCH-5290743
iGMDRD289Parthenolide3
iGMDRD512nutlin 36
iGMDRD255SB2250023
iGMDRD268Cerulenin3
iGMDRD154NSC237666
iGMDRD123Isoevodiamine4
iGMDRD466Chaetocin3
iGMDRD64Parbendazole3
iGMDRD506Fedratinib3
iGMDRD269Purmorphamine3
iGMDRD188Piperlongumine3
iGMDRD446LY 21832404
iGMDRD286Nsc 6328396

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDK3

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