PDK3


Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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GO terms in PDK3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006006 glucose metabolic process
BP IMP GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
BP TAS GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
BP IMP GO:0010906 regulation of glucose metabolic process
BP IDA GO:0018105 peptidyl-serine phosphorylation
BP IMP GO:0035357 peroxisome proliferator activated receptor signaling pathway
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Gene expression in normal tissue: PDK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

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Pathways in PDK3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
reactome R-HSA-5362517 Signaling by Retinoic Acid
reactome R-HSA-70268 Pyruvate metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD483 SCH-529074 3
iGMDRD289 Parthenolide 3
iGMDRD512 nutlin 3 6
iGMDRD255 SB225002 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDK3

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Cancer
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