PDK3
Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pyruvate dehydrogenase kinase 3 | MIM:300906 | Ensembl:ENSG00000067992 | HGNC:HGNC:8811 | PA33156 | Xp22.11 |
GO terms in PDK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IMP | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | TAS | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | IMP | GO:0010906 | regulation of glucose metabolic process |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0035357 | peroxisome proliferator activated receptor signaling pathway |
| BP | ISS | GO:0071333 | cellular response to glucose stimulus |
| BP | IMP | GO:0071398 | cellular response to fatty acid |
| BP | IMP | GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway |
| BP | IMP | GO:2000377 | regulation of reactive oxygen species metabolic process |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | EXP | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | IDA | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: PDK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD286 | Nsc 632839 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDK3
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