SLC22A3
Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 22 member 3 | MIM:604842 | Ensembl:ENSG00000146477 | HGNC:HGNC:10967 | PA330 | 6q25.3 |
GO terms in SLC22A3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0015101 | organic cation transmembrane transporter activity |
| MF | IDA | GO:0015101 | organic cation transmembrane transporter activity |
| MF | TAS | GO:0015101 | organic cation transmembrane transporter activity |
| MF | IDA | GO:0015651 | quaternary ammonium group transmembrane transporter activity |
| MF | IEA | GO:0019534 | toxin transmembrane transporter activity |
| BP | TAS | GO:0006855 | drug transmembrane transport |
| BP | IDA | GO:0015695 | organic cation transport |
| BP | IDA | GO:0015697 | quaternary ammonium group transport |
| BP | IEA | GO:0015711 | organic anion transport |
| BP | IEA | GO:0032098 | regulation of appetite |
| BP | IEA | GO:0051615 | histamine uptake |
| BP | IEA | GO:1901998 | toxin transport |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0016020 | membrane |
Gene expression in normal tissue: SLC22A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC22A3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
| smpdb | SMP00649 | Lamivudine Metabolism Pathway |
| pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA165948259 | Metformin Pathway, Pharmacokinetics |
| pharmgkb | PA2042 | Sympathetic Nerve Pathway (Neuroeffector Junction) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2161517 | Abacavir transmembrane transport |
| reactome | R-HSA-2161522 | Abacavir transport and metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-549127 | Organic cation transport |
| reactome | R-HSA-549132 | Organic cation/anion/zwitterion transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD229 | B02 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD226 | ML006 | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD255 | SB225002 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC22A3
CLASSFICATION
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