SLC22A3
Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604842 Ensembl IDEnsembl:ENSG00000146477 HGNC IDHGNC:HGNC:10967 PHARMGKB IDPA330 Map Location6q25.3 |
GO terms in SLC22A3
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | EXP | GO:0015101 | organic cation transmembrane transporter activity |
MF | IDA | GO:0015101 | organic cation transmembrane transporter activity |
MF | TAS | GO:0015101 | organic cation transmembrane transporter activity |
MF | IDA | GO:0015651 | quaternary ammonium group transmembrane transporter activity |
MF | IEA | GO:0019534 | toxin transmembrane transporter activity |
Gene expression in normal tissue: SLC22A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC22A3
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2267 | Synaptic Vesicle Pathway |
smpdb | SMP00649 | Lamivudine Metabolism Pathway |
pharmgkb | PA165860384 | Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics |
pharmgkb | PA165948259 | Metformin Pathway, Pharmacokinetics |
pharmgkb | PA2042 | Sympathetic Nerve Pathway (Neuroeffector Junction) |
kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SLC22A3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |