SLC22A3

Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesolute carrier family 22 member 3
OMIM IDMIM:604842
Ensembl IDEnsembl:ENSG00000146477
HGNC IDHGNC:HGNC:10967
PHARMGKB IDPA330
Map Location6q25.3

GO terms in SLC22A3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF EXP GO:0015101 organic cation transmembrane transporter activity
MF IDA GO:0015101 organic cation transmembrane transporter activity
MF TAS GO:0015101 organic cation transmembrane transporter activity
MF IDA GO:0015651 quaternary ammonium group transmembrane transporter activity
MF IEA GO:0019534 toxin transmembrane transporter activity
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Gene expression in normal tissue: SLC22A3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21Apoptosis regulation2Leukocyte transendothelial migration1Chromatin histone acetylation1Other, kinases1PI3K/MTOR signaling1Biosynthesis of secondary metabolites1

Pathways in SLC22A3


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Database
Pathway ID
Pathway Des.
wikipathways WP2267 Synaptic Vesicle Pathway
smpdb SMP00649 Lamivudine Metabolism Pathway
pharmgkb PA165860384 Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkb PA165948259 Metformin Pathway, Pharmacokinetics
pharmgkb PA2042 Sympathetic Nerve Pathway (Neuroeffector Junction)
kegg hsa05231 Choline metabolism in cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD297 Austocystin D 2
iGMDRD466 Chaetocin 1
iGMDRD85 Ursolic acid 5
iGMDRD71 Sparfosic acid 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC22A3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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